Benign transient hyperphosphatasemia in juvenile idiopathic arthritis: A case report

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Benign transient hyperphosphatasemia of infancy and early childhood is a self-limiting condition characte-rized by transiently increased serum alkaline phosphatase in the absence of liver, kidney or metabolic bone diseases. It is often accidentally found in children under five years old and it might be associated with a variety of underlying clinical disorders. Its pathophysiology remains unclear. Herein, we report a case of a 4-year-old girl with a 1-year history of persistent oligoarticular Juvenile Idiopathic Arthritis, who was found to have transient hyperphosphatasemia during a periodic check-up. This clinical case underlines the importance of promptly recognizing this benign condition, which avoids unnecessary extensive investigations.

Original languageEnglish
Pages (from-to)317-319
Number of pages3
JournalActa Reumatológica Portuguesa
Issue number4
Publication statusPublished - 1 Oct 2019


  • Hyperphosphatasemia
  • Juvenile idiopa thic arthritis


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