Benign by design: catalyst-free in-water, on-water green chemical methodologies in organic synthesis

Research output: Contribution to journalArticle

395 Citations (Scopus)

Abstract

Catalyst-free reactions developed during the last decade and the latest developments in this emerging field are summarized with a focus on catalyst-free reactions in-water and on-water. Various named reactions, multi-component reactions and the synthesis of heterocyclic compounds are discussed including the use of various energy input systems such as microwave- and ultrasound irradiation, among others. Organic chemists and the practitioners of this art both in academia and industry hopefully will continue to design benign methodologies for organic synthesis in aqueous media under catalyst-free conditions by using alternative energy inputs based on fundamental principles.
Original languageEnglish
Pages (from-to)5522-5551
JournalChemical Society Reviews
Volume42
Issue number12
DOIs
Publication statusPublished - 2013

Keywords

  • ONE-POT SYNTHESIS
  • SOLVENT-FREE CONDITIONS
  • DIELS-ALDER REACTIONS
  • MICROWAVE-ASSISTED SYNTHESIS
  • AZA-MICHAEL REACTION
  • SUPERCRITICAL CARBON-DIOXIDE
  • MANNICH-TYPE REACTIONS
  • BIGINELLI DIHYDROPYRIMIDINE SYNTHESIS
  • COMBINATORIAL LIBRARY SYNTHESIS
  • EMPLOYING STABILIZED YLIDES

Fingerprint Dive into the research topics of 'Benign by design: catalyst-free in-water, on-water green chemical methodologies in organic synthesis'. Together they form a unique fingerprint.

  • Cite this