Bacterial Small RNAs: Diversity of Structure and Function

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Small non-coding RNAs (sRNAs) are key post-transcriptional regulators of gene expression in bacteria, with a diversity of origins, sequences, structures, and modes of action among their members. The variety within these regulatory RNAs makes it difficult to unify this remarkable heterogeneous class of RNA molecules. Structural determinants along with nucleotide sequence play important roles in defining the sRNA ability to interact with their targets. Most sRNAs bind to mRNA targets, either acting as repressors or activators. Nevertheless, the sRNAs themselves are subject to post-transcriptional regulation, either by ribonucleases, RNA chaperones, and other RNA-binding proteins, as well as RNA sponges. In this chapter we summarize the information on structure and function of bacterial sRNAs and provide several examples to better illustrate the broad diversity of this class of regulatory RNAs.

Original languageEnglish
Title of host publicationRNA Technologies
PublisherSpringer Medizin
Pages259-277
Number of pages19
Volume14
ISBN (Electronic) Online ISBN978-3-031-36390-0
ISBN (Print)978-3-031-36389-4
DOIs
Publication statusPublished - 2023

Publication series

NameRNA Technologies
Volume14
ISSN (Print)2197-9731
ISSN (Electronic)2197-9758

Keywords

  • CRISPR
  • Hfq
  • Non-coding RNA
  • Regulatory RNA
  • RNA sequence
  • RNA structure
  • RNA-RNA interaction
  • Sponge RNA
  • sRNA

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