BacHBerry: BACterial Hosts for production of Bioactive phenolics from bERRY fruits

Alexey Dudnik, A. Filipa Almeida, Ricardo Andrade, Barbara Avila, Pilar Bañados, Diane Barbay, Jean Etienne Bassard, Mounir Benkoulouche, Michael Bott, Adelaide Braga, Dario Breitel, Rex Brennan, Laurent Bulteau, Celine Chanforan, Inês Costa, Rafael S. Costa, Mahdi Doostmohammadi, Nuno Faria, Chengyong Feng, Armando FernandesPatricia Ferreira, Roberto Ferro, Alexandre Foito, Sabine Freitag, Gonçalo Garcia, Paula Gaspar, Joana Godinho-Pereira, Björn Hamberger, András Hartmann, Harald Heider, Carolina Jardim, Alice Julien-Laferriere, Nicolai Kallscheuer, Wolfgang Kerbe, Oscar P. Kuipers, Shanshan Li, Nicola Love, Alberto Marchetti-Spaccamela, Jan Marienhagen, Cathie Martin, Arnaud Mary, Vincent Mazurek, Camillo Meinhart, David Méndez Sevillano, Regina Menezes, Michael Naesby, Morten H.H. Nørholm, Finn T. Okkels, Joana Oliveira, Marcel Ottens, Delphine Parrot, Lei Pei, Isabel Rocha, Rita Rosado-Ramos, Caroline Rousseau, Marie France Sagot, Claudia Nunes dos Santos, Markus Schmidt, Tatiana Shelenga, Louise Shepherd, Ana Rita Silva, Marcelo Henriques da Silva, Olivier Simon, Steen Gustav Stahlhut, Ana Solopova, Artem Sorokin, Derek Stewart, Leen Stougie, Shang Su, Vera Thole, Olga Tikhonova, Martin Trick, Philippe Vain, André Veríssimo, Ana Vila-Santa, Susana Vinga, Michael Vogt, Liangsheng Wang, Lijin Wang, Wei Wei, Sandra Youssef, Ana Rute Neves, Jochen Forster

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

BACterial Hosts for production of Bioactive phenolics from bERRY fruits (BacHBerry) was a 3-year project funded by the Seventh Framework Programme (FP7) of the European Union that ran between November 2013 and October 2016. The overall aim of the project was to establish a sustainable and economically-feasible strategy for the production of novel high-value phenolic compounds isolated from berry fruits using bacterial platforms. The project aimed at covering all stages of the discovery and pre-commercialization process, including berry collection, screening and characterization of their bioactive components, identification and functional characterization of the corresponding biosynthetic pathways, and construction of Gram-positive bacterial cell factories producing phenolic compounds. Further activities included optimization of polyphenol extraction methods from bacterial cultures, scale-up of production by fermentation up to pilot scale, as well as societal and economic analyses of the processes. This review article summarizes some of the key findings obtained throughout the duration of the project.

Original languageEnglish
Pages (from-to)291-326
Number of pages36
JournalPhytochemistry Reviews
Volume17
Issue number2
DOIs
Publication statusPublished - 1 Apr 2018

Keywords

  • Berries
  • Bioprospecting
  • Microbial cell factories
  • Polyphenols
  • Sustainable production

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    Dudnik, A., Almeida, A. F., Andrade, R., Avila, B., Bañados, P., Barbay, D., ... Forster, J. (2018). BacHBerry: BACterial Hosts for production of Bioactive phenolics from bERRY fruits. Phytochemistry Reviews, 17(2), 291-326. https://doi.org/10.1007/s11101-017-9532-2