Atherosclerosis risk in antiphospholipid syndrome

Research output: Contribution to journalReview articlepeer-review


The antiphospholipid syndrome is characterized by a clinical phenotype that mimics several aspects present in general atherosclerosis. This association has been supported by the identification of similar biologic pathways that are activated in both conditions. The inflammatory and immune profiles found in these two types of patients are reinforced by the common vascular dysfunction present in general atherosclerosis and in antiphospholipid syndrome. However, these concepts are not matched by the anatomical findings present in both conditions. This suggests that although atherosclerosis may have an important role in antiphospholipid syndrome, the direct pro-thrombotic nature of this condition may be responsible for the majority of the manifestations seen in these patients. © 2011 Future Medicine Ltd.
Original languageEnglish
Pages (from-to)583-593
Number of pages11
JournalInternational Journal of Clinical Rheumatology
Issue number5
Publication statusPublished - Oct 2011


  • antherosclerosis
  • antiphospholipid syndrome
  • inflammation
  • thrombosis
  • aryldialkylphosphatase 1
  • beta2 glycoprotein 1
  • C reactive protein
  • CD40 ligand
  • fluindostatin
  • high density lipoprotein
  • hydroxychloroquine
  • hydroxymethylglutaryl coenzyme A reductase inhibitor
  • intercellular adhesion molecule 1
  • low density lipoprotein
  • oxidized low density lipoprotein
  • phospholipid antibody
  • vascular cell adhesion molecule 1
  • vasculotropin
  • ankle brachial index
  • arterial stiffness
  • arterial wall thickness
  • artery occlusion
  • artery thrombosis
  • atherogenesis
  • atherosclerosis
  • cardiovascular risk
  • disease association
  • endothelial dysfunction
  • fibromuscular dysplasia
  • human
  • hypercholesterolemia
  • lipid peroxidation
  • oxidative stress
  • priority journal
  • review
  • vein thrombosis


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