TY - JOUR
T1 - Association of FAAH rs324420 (C385A) Polymorphism with High-Level Performance in Volleyball Players
AU - Silva, Hugo Henrique
AU - Tavares, Valéria
AU - Silva, Maria Raquel G.
AU - Neto, Beatriz Vieira
AU - Cerqueira, Fátima
AU - Medeiros, Rui
N1 - Funding Information:
This research was supported by research found at ICBAS-PD Biomedical Sciences-200203100 and the Portuguese League Against Cancer—Northern Branch (LPCC-NRN).
Funding Information:
We would like to thank all the volleyball players who participated in this study and the coaches for their collaboration. We would also like to thank the Instituto Português de Oncologia do Porto (IPOP), the Fundação para a Ciência e Tecnologia (FCT), and the Faculty of Health Sciences—University Fernando Pessoa, Porto. V.T. is a PhD scholarship holder (2020.08969.BD) supported by Fundação para a Ciência e Tecnologia (FCT), and co-financed by European Social Funds (FSE) and national funds of MCTES.
Publisher Copyright:
© 2023 by the authors.
PY - 2023/6
Y1 - 2023/6
N2 - Genetic variants are recognized to affect athletic performance, partially by modulating competition-facilitating behavior. In this study, the role of three genetic variants previously linked to athlete status was investigated among elite volleyball players. A total of 228 players (26.7 ± 8.1 years old) participating in the Portuguese championship and with multiple medalists in national and international competitions were evaluated in terms of anthropometrics, training regime, sports experience, and a history of sports lesions. SNP genotyping was conducted by means of TaqMan® Allelic Discrimination Methodology. Volleyball players showed significantly different anthropometric indicators and training habits according to sex (p < 0.05). The A allele of the genetic variant Fatty Acid Amide Hydrolase (FAAH) rs324420 (C385A) was shown to be significantly associated with superior athletic achievements under a dominant genetic model (AA/AC vs. CC, odds ratio (OR) = 1.70; 95% Cl, 0.93–3.13; p = 0.026; p < 0.001 after Bootstrap), which was corroborated by a multivariable analysis (AA/AC vs. CC adjusted OR = 2.00; 95% Cl, 1.04–3.82; p = 0.037). Age and hand length were also found to be independently associated with high-level performance (p < 0.05). Our results confirm the role of FAAH in athletic performance. More investigation into this polymorphism’s potential impact on stress coping, pain, and inflammation regulation in sport, particularly in the scope of lesions prevention and treatment, is required.
AB - Genetic variants are recognized to affect athletic performance, partially by modulating competition-facilitating behavior. In this study, the role of three genetic variants previously linked to athlete status was investigated among elite volleyball players. A total of 228 players (26.7 ± 8.1 years old) participating in the Portuguese championship and with multiple medalists in national and international competitions were evaluated in terms of anthropometrics, training regime, sports experience, and a history of sports lesions. SNP genotyping was conducted by means of TaqMan® Allelic Discrimination Methodology. Volleyball players showed significantly different anthropometric indicators and training habits according to sex (p < 0.05). The A allele of the genetic variant Fatty Acid Amide Hydrolase (FAAH) rs324420 (C385A) was shown to be significantly associated with superior athletic achievements under a dominant genetic model (AA/AC vs. CC, odds ratio (OR) = 1.70; 95% Cl, 0.93–3.13; p = 0.026; p < 0.001 after Bootstrap), which was corroborated by a multivariable analysis (AA/AC vs. CC adjusted OR = 2.00; 95% Cl, 1.04–3.82; p = 0.037). Age and hand length were also found to be independently associated with high-level performance (p < 0.05). Our results confirm the role of FAAH in athletic performance. More investigation into this polymorphism’s potential impact on stress coping, pain, and inflammation regulation in sport, particularly in the scope of lesions prevention and treatment, is required.
KW - FAAH
KW - gene
KW - high-level performance
KW - polymorphism
KW - volleyball
UR - http://www.scopus.com/inward/record.url?scp=85164104333&partnerID=8YFLogxK
U2 - 10.3390/genes14061164
DO - 10.3390/genes14061164
M3 - Article
C2 - 37372343
AN - SCOPUS:85164104333
SN - 0920-8569
VL - 14
JO - Genes
JF - Genes
IS - 6
M1 - 1164
ER -