Association of depressive symptoms with allodynia in patients with migraine: A cross-sectional study

M. Mendonça, André Caetano, CHLO Headache Study Group, Miguel Viana-Baptista

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6 Citations (Scopus)


AIMS: Migraine and depression have a strong association. We aimed to determine whether this relationship was particularly evident in migraineurs with allodynia.

METHODS: A cross-sectional study was carried out of 98 consecutive patients with episodic migraine presenting for their first evaluation in an outpatient clinic. The participants completed a demographic questionnaire, the Allodynia Symptom Checklist and the Hospital Anxiety and Depression Scale (HADS).

RESULTS: Among the migraineurs, 75 (77%) reported allodynia. Allodynia was associated with higher median HADS-Anxiety (9 vs. 6, p = 0.038) and HADS-Depression (6 vs. 4, p = 0.014) scores. In a multiple regression model, the HADS-Depression scores were independently associated with allodynia (odds ratio 1.236, 95% confidence interval 1.046-1.461). An increased severity of allodynia correlated with higher depression scores (r = 0.224; p = 0.027).

CONCLUSION: Anxious and depressive symptoms are more common in migraineurs with allodynia than in those without allodynia. Further studies are necessary to clarify the relationship between depressive symptoms and allodynia, as well as its therapeutic implications in migraine.

Original languageEnglish
Publication statusPublished - 2 Dec 2015


  • Neurology


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