TY - JOUR
T1 - Assessment of gamma oryzanol variability, an attractive rice bran bioactive compound
AU - Lageiro, M. Manuela
AU - Castanho, Ana
AU - Pereira, Cristiana
AU - Calhelha, Ricardo C.
AU - Ferreira, Isabel C.F.R.
AU - Brites, Carla
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Gamma-oryzanol is a compound present on rice bran, which has been studied for its bioactive properties, including its cytotoxic activity. The gamma-oryzanol biosynthesis occurs on the lipidic membrane of the plant and can be influenced by edaphoclimatic grown conditions. Two Portuguese rice varieties (Ceres and Macarico) from 6 growing environments were analysed in order to explore the influence of the growing conditions on the gamma-oryzanol content, its constituents, and cytotoxic effect against 4 human tumour cell lines (NCI-H460, HeLa, HepG2, and MCF-7). The overall variability of gamma-oryzanol concentration was from 1.56 g/Kg to 3.19 g/Kg, Ceres reveals higher values than Macarico; those concentrations also varied with the growing environment. The environment was also determinant for the individual concentration of the 3 gamma-oryzanol compounds (cycloartenyl ferulate, 24-methylenecycloartanyl ferulate, and campesteryl ferulate). A cytotoxic effect was observed for all the tested tumour cell lines and also varied with the growing environment.
AB - Gamma-oryzanol is a compound present on rice bran, which has been studied for its bioactive properties, including its cytotoxic activity. The gamma-oryzanol biosynthesis occurs on the lipidic membrane of the plant and can be influenced by edaphoclimatic grown conditions. Two Portuguese rice varieties (Ceres and Macarico) from 6 growing environments were analysed in order to explore the influence of the growing conditions on the gamma-oryzanol content, its constituents, and cytotoxic effect against 4 human tumour cell lines (NCI-H460, HeLa, HepG2, and MCF-7). The overall variability of gamma-oryzanol concentration was from 1.56 g/Kg to 3.19 g/Kg, Ceres reveals higher values than Macarico; those concentrations also varied with the growing environment. The environment was also determinant for the individual concentration of the 3 gamma-oryzanol compounds (cycloartenyl ferulate, 24-methylenecycloartanyl ferulate, and campesteryl ferulate). A cytotoxic effect was observed for all the tested tumour cell lines and also varied with the growing environment.
KW - Cytotoxicity
KW - Gamma-oryzanol
KW - HPLC
KW - Rice bran
UR - http://www.scopus.com/inward/record.url?scp=85087065652&partnerID=8YFLogxK
U2 - 10.9755/EJFA.2020.V32.I1.2056
DO - 10.9755/EJFA.2020.V32.I1.2056
M3 - Article
AN - SCOPUS:85087065652
SN - 2079-052X
VL - 32
SP - 38
EP - 46
JO - Emirates Journal of Food and Agriculture
JF - Emirates Journal of Food and Agriculture
IS - 1
M1 - 2056
ER -