Arterial stiffness in children and adolescents with and without continuous insulin infusion

Cíntia Castro-Correia, Cláudia Moura, Cláudia Mota, Rita Santos-Silva, J. Carlos Areias, Conceição Calhau, Manuel Fontoura

Research output: Contribution to journalArticle

Abstract

Arterial stiffness is a consequence of aging, but there are several diseases that contribute to this process. The evaluation of pulse wave velocity (PWV) allows a dynamic evaluation of vascular distensibility and the detection of atherosclerosis at an early stage. It was intended to evaluate the PWV in children and adolescents with type 1 diabetes mellitus (T1DM) and to compare their outcome according to the type of treatment used. Forty-eight patients were randomly selected. Inclusion criteria: T1DM, under intensive insulin therapy (multiple daily insulin administrations [MDI] or continuous insulin infusion system [CIIS]). Exclusion criteria: existence of another chronic pathology or microvascular complications. Echocardiography was performed and three measurements of PWV were done, with their mean calculated. Most of the children and adolescents presented a PWV ≥ the 75th centile. There was a statistically significant difference for hemoglobin A1c (HbA1c) (7.8 in CIIS vs. 9 in MDI, p < 0.05). There were not statistically significant differences in the PWV between the two groups. This can be attributed to the fact that children with CIIS are those who previously presented greater glycemic instability. There was a significant correlation between PWV and disease duration (Pearson's correlation coefficient [r] = 0.314, p = 0.036). This study showed that in children and adolescents with T1DM, there is an important prevalence of arterial stiffness, translated by an increase in PWV. This increase in PWV appears to exist even in very young children with little disease evolution time.

Original languageEnglish
Pages (from-to)837-841
JournalJournal of Pediatric Endocrinology and Metabolism
Volume32
Issue number8
DOIs
Publication statusPublished - Aug 2019

Fingerprint

Pulse Wave Analysis
Vascular Stiffness
Insulin
Insulin Infusion Systems
Type 1 Diabetes Mellitus
Cerebral Palsy
Blood Vessels
Echocardiography
Atherosclerosis
Hemoglobins
Pathology
Therapeutics

Keywords

  • arterial stiffness
  • pulse wave velocity
  • type 1 diabetes

Cite this

Castro-Correia, Cíntia ; Moura, Cláudia ; Mota, Cláudia ; Santos-Silva, Rita ; Areias, J. Carlos ; Calhau, Conceição ; Fontoura, Manuel. / Arterial stiffness in children and adolescents with and without continuous insulin infusion. In: Journal of Pediatric Endocrinology and Metabolism. 2019 ; Vol. 32, No. 8. pp. 837-841.
@article{c0487e26dae14ebda3d8092d5e18aff7,
title = "Arterial stiffness in children and adolescents with and without continuous insulin infusion",
abstract = "Arterial stiffness is a consequence of aging, but there are several diseases that contribute to this process. The evaluation of pulse wave velocity (PWV) allows a dynamic evaluation of vascular distensibility and the detection of atherosclerosis at an early stage. It was intended to evaluate the PWV in children and adolescents with type 1 diabetes mellitus (T1DM) and to compare their outcome according to the type of treatment used. Forty-eight patients were randomly selected. Inclusion criteria: T1DM, under intensive insulin therapy (multiple daily insulin administrations [MDI] or continuous insulin infusion system [CIIS]). Exclusion criteria: existence of another chronic pathology or microvascular complications. Echocardiography was performed and three measurements of PWV were done, with their mean calculated. Most of the children and adolescents presented a PWV ≥ the 75th centile. There was a statistically significant difference for hemoglobin A1c (HbA1c) (7.8 in CIIS vs. 9 in MDI, p < 0.05). There were not statistically significant differences in the PWV between the two groups. This can be attributed to the fact that children with CIIS are those who previously presented greater glycemic instability. There was a significant correlation between PWV and disease duration (Pearson's correlation coefficient [r] = 0.314, p = 0.036). This study showed that in children and adolescents with T1DM, there is an important prevalence of arterial stiffness, translated by an increase in PWV. This increase in PWV appears to exist even in very young children with little disease evolution time.",
keywords = "arterial stiffness, pulse wave velocity, type 1 diabetes",
author = "C{\'i}ntia Castro-Correia and Cl{\'a}udia Moura and Cl{\'a}udia Mota and Rita Santos-Silva and Areias, {J. Carlos} and Concei{\cc}{\~a}o Calhau and Manuel Fontoura",
year = "2019",
month = "8",
doi = "10.1515/jpem-2019-0102",
language = "English",
volume = "32",
pages = "837--841",
journal = "Journal Of Pediatric Endocrinology & Metabolism",
issn = "0334-018X",
publisher = "Freund Publishing House",
number = "8",

}

Arterial stiffness in children and adolescents with and without continuous insulin infusion. / Castro-Correia, Cíntia; Moura, Cláudia; Mota, Cláudia; Santos-Silva, Rita; Areias, J. Carlos; Calhau, Conceição; Fontoura, Manuel.

In: Journal of Pediatric Endocrinology and Metabolism, Vol. 32, No. 8, 08.2019, p. 837-841.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Arterial stiffness in children and adolescents with and without continuous insulin infusion

AU - Castro-Correia, Cíntia

AU - Moura, Cláudia

AU - Mota, Cláudia

AU - Santos-Silva, Rita

AU - Areias, J. Carlos

AU - Calhau, Conceição

AU - Fontoura, Manuel

PY - 2019/8

Y1 - 2019/8

N2 - Arterial stiffness is a consequence of aging, but there are several diseases that contribute to this process. The evaluation of pulse wave velocity (PWV) allows a dynamic evaluation of vascular distensibility and the detection of atherosclerosis at an early stage. It was intended to evaluate the PWV in children and adolescents with type 1 diabetes mellitus (T1DM) and to compare their outcome according to the type of treatment used. Forty-eight patients were randomly selected. Inclusion criteria: T1DM, under intensive insulin therapy (multiple daily insulin administrations [MDI] or continuous insulin infusion system [CIIS]). Exclusion criteria: existence of another chronic pathology or microvascular complications. Echocardiography was performed and three measurements of PWV were done, with their mean calculated. Most of the children and adolescents presented a PWV ≥ the 75th centile. There was a statistically significant difference for hemoglobin A1c (HbA1c) (7.8 in CIIS vs. 9 in MDI, p < 0.05). There were not statistically significant differences in the PWV between the two groups. This can be attributed to the fact that children with CIIS are those who previously presented greater glycemic instability. There was a significant correlation between PWV and disease duration (Pearson's correlation coefficient [r] = 0.314, p = 0.036). This study showed that in children and adolescents with T1DM, there is an important prevalence of arterial stiffness, translated by an increase in PWV. This increase in PWV appears to exist even in very young children with little disease evolution time.

AB - Arterial stiffness is a consequence of aging, but there are several diseases that contribute to this process. The evaluation of pulse wave velocity (PWV) allows a dynamic evaluation of vascular distensibility and the detection of atherosclerosis at an early stage. It was intended to evaluate the PWV in children and adolescents with type 1 diabetes mellitus (T1DM) and to compare their outcome according to the type of treatment used. Forty-eight patients were randomly selected. Inclusion criteria: T1DM, under intensive insulin therapy (multiple daily insulin administrations [MDI] or continuous insulin infusion system [CIIS]). Exclusion criteria: existence of another chronic pathology or microvascular complications. Echocardiography was performed and three measurements of PWV were done, with their mean calculated. Most of the children and adolescents presented a PWV ≥ the 75th centile. There was a statistically significant difference for hemoglobin A1c (HbA1c) (7.8 in CIIS vs. 9 in MDI, p < 0.05). There were not statistically significant differences in the PWV between the two groups. This can be attributed to the fact that children with CIIS are those who previously presented greater glycemic instability. There was a significant correlation between PWV and disease duration (Pearson's correlation coefficient [r] = 0.314, p = 0.036). This study showed that in children and adolescents with T1DM, there is an important prevalence of arterial stiffness, translated by an increase in PWV. This increase in PWV appears to exist even in very young children with little disease evolution time.

KW - arterial stiffness

KW - pulse wave velocity

KW - type 1 diabetes

UR - http://www.scopus.com/inward/record.url?scp=85068417338&partnerID=8YFLogxK

U2 - 10.1515/jpem-2019-0102

DO - 10.1515/jpem-2019-0102

M3 - Article

VL - 32

SP - 837

EP - 841

JO - Journal Of Pediatric Endocrinology & Metabolism

JF - Journal Of Pediatric Endocrinology & Metabolism

SN - 0334-018X

IS - 8

ER -