16 Citations (Scopus)

Abstract

Members of the ADP-ribosylation factor (Arf) family of small GTP-binding (G) proteins regulate several aspects of membrane trafficking, such as vesicle budding, tethering and cytoskeleton organization. Arf family members, including Arf-like (Arl) proteins have been implicated in several essential cellular functions, like cell spreading and migration. These functions are used by cancer cells to disseminate and invade the tissues surrounding the primary tumor, leading to the formation of metastases. Indeed, Arf and Arl proteins, as well as their guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs) have been found to be abnormally expressed in different cancer cell types and human cancers. Here, we review the current evidence supporting the involvement of Arf family proteins and their GEFs and GAPs in cancer progression, focusing on 3 different mechanisms: cell-cell adhesion, integrin internalization and recycling, and actin cytoskeleton remodeling.

Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalSmall GTPases
DOIs
Publication statusPublished - 2 Sep 2016

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ADP-Ribosylation Factors
Cell Movement
GTPase-Activating Proteins
Guanine Nucleotide Exchange Factors
Cells
Neoplasms
Proteins
GTP-Binding Proteins
Cell adhesion
Guanosine Triphosphate
Integrins
Recycling
Actins
Tumors
Tissue
Membranes
Cytoskeleton
Actin Cytoskeleton
Cell Adhesion
ADP-ribosylation factor related proteins

Cite this

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title = "Arf proteins in cancer cell migration",
abstract = "Members of the ADP-ribosylation factor (Arf) family of small GTP-binding (G) proteins regulate several aspects of membrane trafficking, such as vesicle budding, tethering and cytoskeleton organization. Arf family members, including Arf-like (Arl) proteins have been implicated in several essential cellular functions, like cell spreading and migration. These functions are used by cancer cells to disseminate and invade the tissues surrounding the primary tumor, leading to the formation of metastases. Indeed, Arf and Arl proteins, as well as their guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs) have been found to be abnormally expressed in different cancer cell types and human cancers. Here, we review the current evidence supporting the involvement of Arf family proteins and their GEFs and GAPs in cancer progression, focusing on 3 different mechanisms: cell-cell adhesion, integrin internalization and recycling, and actin cytoskeleton remodeling.",
author = "Cristina Casalou and Alexandra Faustino and Barral, {Duarte C}",
year = "2016",
month = "9",
day = "2",
doi = "10.1080/21541248.2016.1228792",
language = "English",
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journal = "Small GTPases",
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Arf proteins in cancer cell migration. / Casalou, Cristina; Faustino, Alexandra; Barral, Duarte C.

In: Small GTPases, 02.09.2016, p. 1-13.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Arf proteins in cancer cell migration

AU - Casalou, Cristina

AU - Faustino, Alexandra

AU - Barral, Duarte C

PY - 2016/9/2

Y1 - 2016/9/2

N2 - Members of the ADP-ribosylation factor (Arf) family of small GTP-binding (G) proteins regulate several aspects of membrane trafficking, such as vesicle budding, tethering and cytoskeleton organization. Arf family members, including Arf-like (Arl) proteins have been implicated in several essential cellular functions, like cell spreading and migration. These functions are used by cancer cells to disseminate and invade the tissues surrounding the primary tumor, leading to the formation of metastases. Indeed, Arf and Arl proteins, as well as their guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs) have been found to be abnormally expressed in different cancer cell types and human cancers. Here, we review the current evidence supporting the involvement of Arf family proteins and their GEFs and GAPs in cancer progression, focusing on 3 different mechanisms: cell-cell adhesion, integrin internalization and recycling, and actin cytoskeleton remodeling.

AB - Members of the ADP-ribosylation factor (Arf) family of small GTP-binding (G) proteins regulate several aspects of membrane trafficking, such as vesicle budding, tethering and cytoskeleton organization. Arf family members, including Arf-like (Arl) proteins have been implicated in several essential cellular functions, like cell spreading and migration. These functions are used by cancer cells to disseminate and invade the tissues surrounding the primary tumor, leading to the formation of metastases. Indeed, Arf and Arl proteins, as well as their guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs) have been found to be abnormally expressed in different cancer cell types and human cancers. Here, we review the current evidence supporting the involvement of Arf family proteins and their GEFs and GAPs in cancer progression, focusing on 3 different mechanisms: cell-cell adhesion, integrin internalization and recycling, and actin cytoskeleton remodeling.

U2 - 10.1080/21541248.2016.1228792

DO - 10.1080/21541248.2016.1228792

M3 - Article

SP - 1

EP - 13

JO - Small GTPases

JF - Small GTPases

SN - 2154-1248

ER -