Are proinflammatory cytokines relevant for the diagnosis of prostate cancer?

Manuel M. Garrido, Ruy M. Ribeiro, Kimberly Krüger, Luís C. Pinheiro, João T. Guimarães, Stefan Holdenrieder

Research output: Contribution to journalArticlepeer-review

Abstract

Background/Aim: Inflammation plays an important role in prostate cancer (PCa). We evaluated proinflammatory cytokines regarding differential diagnosis of PCa in men with PSA levels between 2-10 ng/ml. Patients and Methods: Serum samples of 79 men (PSA 2-10 ng/ml) were analyzed for 10 proinflammatory cytokines (IL-6, IL-8, TNF-α, IFN-γ, IL-10, IL-1β, IL-2, IL-4, IL-12p70, IL-13) and results were evaluated regarding presence of PCa and disease severity. Results: Significant differences between PCa patients and controls were found for IL-6 (p=0.002), IL-8 (p=0.030), and TNF-α (p=0.009), although they were not predictors of PCa in a logistic regression analysis. In addition, IL-6 and TNF-α levels were significantly higher in patients with high-risk PCa (p<0.05). No significant differences were observed regarding the other cytokines. Conclusion: In patients with PSA levels between 2-10 ng/ml, IL-6, IL-8, and TNF-α are associated with PCa, and IL-6 and TNF-α are associated with high-risk PCa.

Original languageEnglish
Pages (from-to)3067-3073
Number of pages7
JournalAnticancer Research
Volume41
Issue number6
DOIs
Publication statusPublished - Jun 2021

Keywords

  • IL-6
  • IL-8
  • Proinflammatory cytokines
  • Prostate cancer
  • TNF-α

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