Application of Dithiocarbamates as potential new antitrypanosomatids-drugs:: approach chemistry, functional and biological

Oliveira,  Johny Wysllas de Freitas; Rocha,  Hugo Alexandre Oliveira; de Medeiros,  Wendy Marina Toscano Queiroz; MS Silva

doi:10.3390/molecules24152806

Application of Dithiocarbamates as potential new antitrypanosomatids-drugs: approach chemistry, functional and biological

Oliveira, Johny Wysllas de Freitas, Rocha, Hugo Alexandre Oliveira, de Medeiros, Wendy Marina Toscano Queiroz, MS Silva

Research output: Contribution to journal › Review article › peer-review

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Abstract

Dithiocarbamates represent a class of compounds that were evaluated in different biomedical applications because of their chemical versatility. For this reason, several pharmacological activities have already been attributed to these compounds, such as antiparasitic, antiviral, antifungal activities, among others. Therefore, compounds that are based on dithiocarbamates have been evaluated in different in vivo and in vitro models as potential new antimicrobials. Thus, the purpose of this review is to present the possibilities of using dithiocarbamate compounds as potential new antitrypanosomatids-drugs, which could be used for the pharmacological control of Chagas disease, leishmaniasis, and African trypanosomiasis.

Original language	English
Pages (from-to)	E2806-E2820
Number of pages	14
Journal	Molecules
Volume	Vol. 24
Issue number	n.º 15
DOIs	https://doi.org/10.3390/molecules24152806
Publication status	Published - 1 Aug 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

African trypanosomiasis
Chagas disease
DETC
Trypanosomatids
Antiparasitic activity
Dithiocarbamates
Leishmaniasis

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10.3390/molecules24152806Licence: CC BY

Application of Dithiocarbamates as Potential NewFinal published version, 1.87 MBLicence: CC BY

Cite this

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title = "Application of Dithiocarbamates as potential new antitrypanosomatids-drugs:: approach chemistry, functional and biological",

abstract = "Dithiocarbamates represent a class of compounds that were evaluated in different biomedical applications because of their chemical versatility. For this reason, several pharmacological activities have already been attributed to these compounds, such as antiparasitic, antiviral, antifungal activities, among others. Therefore, compounds that are based on dithiocarbamates have been evaluated in different in vivo and in vitro models as potential new antimicrobials. Thus, the purpose of this review is to present the possibilities of using dithiocarbamate compounds as potential new antitrypanosomatids-drugs, which could be used for the pharmacological control of Chagas disease, leishmaniasis, and African trypanosomiasis.",

keywords = "African trypanosomiasis, Chagas disease, DETC, Trypanosomatids, Antiparasitic activity, Dithiocarbamates, Leishmaniasis",

author = "\{Johny Wysllas de Freitas\}, Oliveira, and \{Hugo Alexandre Oliveira\}, Rocha, and \{Wendy Marina Toscano Queiroz\}, \{de Medeiros,\} and MS Silva",

year = "2019",

month = aug,

day = "1",

doi = "10.3390/molecules24152806",

language = "English",

volume = "Vol. 24",

pages = "E2806--E2820",

journal = "Molecules",

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Application of Dithiocarbamates as potential new antitrypanosomatids-drugs: approach chemistry, functional and biological. / Johny Wysllas de Freitas, Oliveira, ; Hugo Alexandre Oliveira, Rocha,; Wendy Marina Toscano Queiroz, de Medeiros, et al.
In: Molecules, Vol. Vol. 24, No. n.º 15, 01.08.2019, p. E2806-E2820.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - Application of Dithiocarbamates as potential new antitrypanosomatids-drugs:

T2 - approach chemistry, functional and biological

AU - Johny Wysllas de Freitas, Oliveira,

AU - Hugo Alexandre Oliveira, Rocha,

AU - Wendy Marina Toscano Queiroz, de Medeiros,

AU - Silva, MS

PY - 2019/8/1

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N2 - Dithiocarbamates represent a class of compounds that were evaluated in different biomedical applications because of their chemical versatility. For this reason, several pharmacological activities have already been attributed to these compounds, such as antiparasitic, antiviral, antifungal activities, among others. Therefore, compounds that are based on dithiocarbamates have been evaluated in different in vivo and in vitro models as potential new antimicrobials. Thus, the purpose of this review is to present the possibilities of using dithiocarbamate compounds as potential new antitrypanosomatids-drugs, which could be used for the pharmacological control of Chagas disease, leishmaniasis, and African trypanosomiasis.

AB - Dithiocarbamates represent a class of compounds that were evaluated in different biomedical applications because of their chemical versatility. For this reason, several pharmacological activities have already been attributed to these compounds, such as antiparasitic, antiviral, antifungal activities, among others. Therefore, compounds that are based on dithiocarbamates have been evaluated in different in vivo and in vitro models as potential new antimicrobials. Thus, the purpose of this review is to present the possibilities of using dithiocarbamate compounds as potential new antitrypanosomatids-drugs, which could be used for the pharmacological control of Chagas disease, leishmaniasis, and African trypanosomiasis.

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JF - Molecules

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