TY - JOUR
T1 - Application of Dithiocarbamates as potential new antitrypanosomatids-drugs:
T2 - approach chemistry, functional and biological
AU - Johny Wysllas de Freitas, Oliveira,
AU - Hugo Alexandre Oliveira, Rocha,
AU - Wendy Marina Toscano Queiroz, de Medeiros,
AU - Silva, MS
PY - 2019/8/1
Y1 - 2019/8/1
N2 - Dithiocarbamates represent a class of compounds that were evaluated in different biomedical applications because of their chemical versatility. For this reason, several pharmacological activities have already been attributed to these compounds, such as antiparasitic, antiviral, antifungal activities, among others. Therefore, compounds that are based on dithiocarbamates have been evaluated in different in vivo and in vitro models as potential new antimicrobials. Thus, the purpose of this review is to present the possibilities of using dithiocarbamate compounds as potential new antitrypanosomatids-drugs, which could be used for the pharmacological control of Chagas disease, leishmaniasis, and African trypanosomiasis.
AB - Dithiocarbamates represent a class of compounds that were evaluated in different biomedical applications because of their chemical versatility. For this reason, several pharmacological activities have already been attributed to these compounds, such as antiparasitic, antiviral, antifungal activities, among others. Therefore, compounds that are based on dithiocarbamates have been evaluated in different in vivo and in vitro models as potential new antimicrobials. Thus, the purpose of this review is to present the possibilities of using dithiocarbamate compounds as potential new antitrypanosomatids-drugs, which could be used for the pharmacological control of Chagas disease, leishmaniasis, and African trypanosomiasis.
KW - African trypanosomiasis
KW - Chagas disease
KW - DETC
KW - Trypanosomatids
KW - Antiparasitic activity
KW - Dithiocarbamates
KW - Leishmaniasis
UR - https://www.mdpi.com/1420-3049/24/15/2806
U2 - 10.3390/molecules24152806
DO - 10.3390/molecules24152806
M3 - Review article
C2 - 31374887
VL - Vol. 24
SP - E2806-E2820
JO - Molecules
JF - Molecules
IS - n.º 15
ER -