TY - JOUR
T1 - Anything but Conventional Chromatography Approaches in Bioseparation
AU - Roque, Ana Cecília Afonso
AU - Pina, Ana Sofia
AU - Azevedo, Ana Margarida
AU - Aires-Barros, Raquel
AU - Jungbauer, Alois
AU - Di Profio, Gianluca
AU - Heng, Jerry Y. Y.
AU - Haigh, Jonathan
AU - Ottens, Marcel
N1 - info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F97585%2F2013/PT#
PTDC/BII-BIO/28878/2017
UIDB/04378/2020
UID/BIO/04565/2020
POCI-01-0145-FEDER-007728
LISBOA-01-0145-FEDER-028878
Future Fellowship (EP/N015916/1)
Sem PDF conforme despacho.
PY - 2020/8/1
Y1 - 2020/8/1
N2 - While packed bed chromatography, known as conventional chromatography, has been serving the biopharmaceutical industry for decades as the bioseparation method of choice, alternative approaches are likely to take an increasing leading role in the next few years. The high number of new biological drugs under development, and the need to make biopharmaceuticals widely accessible, has been driving the academia and industry in the quest of anything but conventional chromatography approaches. In this perspective paper, these alternative approaches are discussed in view of current and future challenges in the downstream processing field.
AB - While packed bed chromatography, known as conventional chromatography, has been serving the biopharmaceutical industry for decades as the bioseparation method of choice, alternative approaches are likely to take an increasing leading role in the next few years. The high number of new biological drugs under development, and the need to make biopharmaceuticals widely accessible, has been driving the academia and industry in the quest of anything but conventional chromatography approaches. In this perspective paper, these alternative approaches are discussed in view of current and future challenges in the downstream processing field.
KW - aqueous-two phase systems
KW - continuous and integrated processes
KW - crystallization
KW - high throughput process development
KW - membrane technology
KW - non-conventional chromatography
UR - http://www.scopus.com/inward/record.url?scp=85084432263&partnerID=8YFLogxK
U2 - 10.1002/biot.201900274
DO - 10.1002/biot.201900274
M3 - Article
C2 - 32333634
AN - SCOPUS:85084432263
SN - 1860-6768
VL - 15
JO - Biotechnology Journal
JF - Biotechnology Journal
IS - 8
M1 - 1900274
ER -