Antiplasmodial activity of lignans and extracts from Pycnanthus angolensis

Marta Abrantes, Tânia Mil-Homens, Noélia Duarte, Dinora Lopes, Pedro Cravo, Maria Do Céu Madureira, Maria José U. Ferreira

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The dichloromethane, methanol and aqueous ethanol extracts of the stem bark of Pycnanthus angolensis were evaluated for their in vitro activity against the 3D7 Plasmodium falciparum strain. The CH2C12 extract was the most active showing an 1C50= 1.6 μg/ mL. From this extract, a new dibenzylbutane lignan, threo-4,4′-dihydroxy-3-methoxylignan (1) named pycnantolol, together with the known lignans (-)-dihydroguaiaretic acid (2), helio-buphthalmin (3), talaumidin (4), hinokinin (5), the labdane-type diterpene ozic acid (6), and the steroids stigmast-4-en-6β-ol-3-one (7), β3-sitosterol (8) and stigmasterol (9) were isolated. Their structures were established on the basis of physical and spectroscopic methods, including 2 D NMR experiments (COSY, HMQC, HMBC and NOESY). The antimalarial activity of compounds 1-7 was evaluated against 3D7 and Dd2 P. falciparum strains. Despite the significant activity displayed by the crude CH2C12 extract, the isolated compounds showed weaker antiplasmodial activity. The lowest IC50 value was obtained for talaumidin (4) (IC50 = 20.7μg/mL against the Dd2-chloroquine resistant P. falciparum strain).

Original languageEnglish
Pages (from-to)1408-1412
Number of pages5
JournalPlanta Medica
Volume74
Issue number11
DOIs
Publication statusPublished - 1 Sep 2008

Keywords

  • Antimalarial activity
  • Lignans
  • Myristicaceae
  • Plasmodium falciparum
  • Pycnanthus angolensis

UN Sustainable Development Goals (SDGs)

  • SDG 3 - Good Health and Well-Being

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