Antiphospholipid antibodies and atherosclerosis: Insights from systemic lupus erythematosus and primary antiphospholipid syndrome

Paul R.J. Ames, Annamaria Margarita, Jose Delgado Alves

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

The issue of atherosclerosis in the antiphospholipid syndrome (APS) is receiving considerable attention within and without the autoimmune settting. Measurement of arterial intima media thickness (IMT) of is an easy and surrogate means of detecting subclinical atherosclerosis. This technique has been applied to patients with systemic lupus erythematosus (SLE) nand primary APS in the attempt to unravel a possible association between antiphospholipid antibodies and premature atherosclerosis. The available data is reviewed in the light of the most recent atherogenic pathways that may differentially account for premature vascular disease in SLE and primary APS.

Original languageEnglish
Pages (from-to)29-35
Number of pages7
JournalClinical Reviews in Allergy and Immunology
Volume37
Issue number1
DOIs
Publication statusPublished - 2009

Keywords

  • Antiphospholipid antibodies
  • Atherosclerosis
  • Primary antiphospholipid syndrome
  • Systemic lupus erythematosus

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