Antioxidising activity of cinnamic acid derivatives against oxidative stress induced by oxidising radicals

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Abstract

Cinnamic acid and its derivatives react with hydroxyl radical (HO center dot), in neutral medium, to give hydroxylation products, whether on the benzene ring or on the exocyclic chain, and decarboxylation products. The latter compounds are also obtained after oxidation of the same substrates by the SO4 center dot radical anion. Evidence was provided for the protecting effects afforded by cinnamic acid and hydroxylated derivatives against oxidative reaction mediated by HO center dot. By using adenine as a model compound, the results obtained suggest that the high protective effect is due to an antioxidising cascade process.
Original languageUnknown
Pages (from-to)432-439
JournalJournal Of Physical Organic Chemistry
Volume26
Issue number5
DOIs
Publication statusPublished - 1 Jan 2013

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