Antimicrobial and Efflux Inhibitor Activity of Usnic Acid Against Mycobacterium abscessus

Ivy B. Ramis, Júlia S. Vianna, Ana Júlia Reis, Andrea von Groll, Daniela F. Ramos, Miguel Viveiros, Pedro E.Almeida da Silva

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

New drugs are needed to treat infections with antimicrobial-resistant Mycobacterium abscessus ; therefore, we evaluated usnic acid as an antimicrobial agent and efflux inhibitor (EI) against M. abscessus . Usnic acid showed antimicrobial activity, and synergistically, the EI verapamil increased this activity. In addition, when we evaluated the interaction of antimicrobials with usnic acid, the increase of their activity was observed. Finally, usnic acid showed an efflux inhibitory effect between the classical EIs verapamil and carbonyl cyanide m-chlorophenylhydrazine. In conclusion, usnic acid showed both antimicrobial and EI activity, indicating that this natural compound may be a promising scaffold for new drugs against this difficult-to-treat microorganism.

Original languageEnglish
Pages (from-to)1265-1270
Number of pages5
JournalPlanta Medica
VolumeVol. 84
Issue numbern.º 17
DOIs
Publication statusAccepted/In press - 18 Jun 2018

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Mycobacterium
Verapamil
Anti-Infective Agents
Scaffolds
Pharmaceutical Preparations
Microorganisms
usnic acid
Infection

Keywords

  • antimicrobial
  • efflux inhibitor
  • Mycobacterium abscessus
  • usnic acid
  • verapamil

Cite this

Ramis, I. B., Vianna, J. S., Reis, A. J., von Groll, A., Ramos, D. F., Viveiros, M., & da Silva, P. E. A. (Accepted/In press). Antimicrobial and Efflux Inhibitor Activity of Usnic Acid Against Mycobacterium abscessus. Planta Medica, Vol. 84(n.º 17), 1265-1270. https://doi.org/10.1055/a-0639-5412
Ramis, Ivy B. ; Vianna, Júlia S. ; Reis, Ana Júlia ; von Groll, Andrea ; Ramos, Daniela F. ; Viveiros, Miguel ; da Silva, Pedro E.Almeida. / Antimicrobial and Efflux Inhibitor Activity of Usnic Acid Against Mycobacterium abscessus. In: Planta Medica. 2018 ; Vol. Vol. 84, No. n.º 17. pp. 1265-1270.
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Ramis, IB, Vianna, JS, Reis, AJ, von Groll, A, Ramos, DF, Viveiros, M & da Silva, PEA 2018, 'Antimicrobial and Efflux Inhibitor Activity of Usnic Acid Against Mycobacterium abscessus', Planta Medica, vol. Vol. 84, no. n.º 17, pp. 1265-1270. https://doi.org/10.1055/a-0639-5412

Antimicrobial and Efflux Inhibitor Activity of Usnic Acid Against Mycobacterium abscessus. / Ramis, Ivy B.; Vianna, Júlia S.; Reis, Ana Júlia; von Groll, Andrea; Ramos, Daniela F.; Viveiros, Miguel; da Silva, Pedro E.Almeida.

In: Planta Medica, Vol. Vol. 84, No. n.º 17, 18.06.2018, p. 1265-1270.

Research output: Contribution to journalArticle

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Ramis IB, Vianna JS, Reis AJ, von Groll A, Ramos DF, Viveiros M et al. Antimicrobial and Efflux Inhibitor Activity of Usnic Acid Against Mycobacterium abscessus. Planta Medica. 2018 Jun 18;Vol. 84(n.º 17):1265-1270. https://doi.org/10.1055/a-0639-5412