Abstract
A library of C3–C5 unsaturated 6-O-sucrose esters have been investigated for their antibacterial, antifungal, and cytotoxic activities. Most of the target compounds showed good inhibitory activity against a variety of clinically and food contaminant important microbial pathogens. In particular, 6-O-methacryloyl sucrose 2 and 1′,2,3,3′,4,4′,6′-hepta-O-acetyl-6-O-methacryloyl sucrose 9 were the most active bactericides against all the tested bacteria with minimal inhibitory concentrations (MICs) ranging between 0.24 and 1.40 μM. The compound 9 showed also the highest antifungal activity with MICs from 0.28 to 1.10 μM. The synthesized compounds possessed low cytotoxicity against human breast, lung, cervical, and hepatocellular carcinoma cell lines without showing toxicity for non-tumor liver cells. Thus, this library of short carbon chain unsaturated sucrose esters represent promising leads for the development of new generation of sucrose-based antimicrobial agents.
| Original language | English |
|---|---|
| Pages (from-to) | 980-988 |
| Number of pages | 9 |
| Journal | Medicinal Chemistry Research |
| Volume | 27 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1 Mar 2018 |
Fingerprint
Keywords
- Antibacterial activity
- Antifungal activity
- Cytotoxic activity
- Sucrose
- Unsaturated esters
Cite this
}
Antimicrobial and cytotoxic activities of short carbon chain unsaturated sucrose esters. / Petrova, Krasimira T.; Barros, M. Teresa; Calhelha, Ricardo C.; Soković, Marina; Ferreira, Isabel C.F.R.
In: Medicinal Chemistry Research, Vol. 27, No. 3, 01.03.2018, p. 980-988.Research output: Contribution to journal › Article
TY - JOUR
T1 - Antimicrobial and cytotoxic activities of short carbon chain unsaturated sucrose esters
AU - Petrova, Krasimira T.
AU - Barros, M. Teresa
AU - Calhelha, Ricardo C.
AU - Soković, Marina
AU - Ferreira, Isabel C.F.R.
N1 - info:eu-repo/grantAgreement/FCT/COMPETE/132972/PT# info:eu-repo/grantAgreement/FCT/5876/135938/PT# sem pdf conforme despacho. The authors thank Serbian Ministry of Education, Science, and Technological Development for financial support (grant number 173032).
PY - 2018/3/1
Y1 - 2018/3/1
N2 - A library of C3–C5 unsaturated 6-O-sucrose esters have been investigated for their antibacterial, antifungal, and cytotoxic activities. Most of the target compounds showed good inhibitory activity against a variety of clinically and food contaminant important microbial pathogens. In particular, 6-O-methacryloyl sucrose 2 and 1′,2,3,3′,4,4′,6′-hepta-O-acetyl-6-O-methacryloyl sucrose 9 were the most active bactericides against all the tested bacteria with minimal inhibitory concentrations (MICs) ranging between 0.24 and 1.40 μM. The compound 9 showed also the highest antifungal activity with MICs from 0.28 to 1.10 μM. The synthesized compounds possessed low cytotoxicity against human breast, lung, cervical, and hepatocellular carcinoma cell lines without showing toxicity for non-tumor liver cells. Thus, this library of short carbon chain unsaturated sucrose esters represent promising leads for the development of new generation of sucrose-based antimicrobial agents.
AB - A library of C3–C5 unsaturated 6-O-sucrose esters have been investigated for their antibacterial, antifungal, and cytotoxic activities. Most of the target compounds showed good inhibitory activity against a variety of clinically and food contaminant important microbial pathogens. In particular, 6-O-methacryloyl sucrose 2 and 1′,2,3,3′,4,4′,6′-hepta-O-acetyl-6-O-methacryloyl sucrose 9 were the most active bactericides against all the tested bacteria with minimal inhibitory concentrations (MICs) ranging between 0.24 and 1.40 μM. The compound 9 showed also the highest antifungal activity with MICs from 0.28 to 1.10 μM. The synthesized compounds possessed low cytotoxicity against human breast, lung, cervical, and hepatocellular carcinoma cell lines without showing toxicity for non-tumor liver cells. Thus, this library of short carbon chain unsaturated sucrose esters represent promising leads for the development of new generation of sucrose-based antimicrobial agents.
KW - Antibacterial activity
KW - Antifungal activity
KW - Cytotoxic activity
KW - Sucrose
KW - Unsaturated esters
UR - http://www.scopus.com/inward/record.url?scp=85035143067&partnerID=8YFLogxK
U2 - 10.1007/s00044-017-2121-5
DO - 10.1007/s00044-017-2121-5
M3 - Article
VL - 27
SP - 980
EP - 988
JO - Medicinal Chemistry Research
JF - Medicinal Chemistry Research
SN - 1054-2523
IS - 3
ER -