Antimicrobial and cytotoxic activities of short carbon chain unsaturated sucrose esters

Krasimira T. Petrova, M. Teresa Barros, Ricardo C. Calhelha, Marina Soković, Isabel C.F.R. Ferreira

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A library of C3–C5 unsaturated 6-O-sucrose esters have been investigated for their antibacterial, antifungal, and cytotoxic activities. Most of the target compounds showed good inhibitory activity against a variety of clinically and food contaminant important microbial pathogens. In particular, 6-O-methacryloyl sucrose 2 and 1′,2,3,3′,4,4′,6′-hepta-O-acetyl-6-O-methacryloyl sucrose 9 were the most active bactericides against all the tested bacteria with minimal inhibitory concentrations (MICs) ranging between 0.24 and 1.40 μM. The compound 9 showed also the highest antifungal activity with MICs from 0.28 to 1.10 μM. The synthesized compounds possessed low cytotoxicity against human breast, lung, cervical, and hepatocellular carcinoma cell lines without showing toxicity for non-tumor liver cells. Thus, this library of short carbon chain unsaturated sucrose esters represent promising leads for the development of new generation of sucrose-based antimicrobial agents.

Original languageEnglish
Pages (from-to)980-988
Number of pages9
JournalMedicinal Chemistry Research
Volume27
Issue number3
DOIs
Publication statusPublished - 1 Mar 2018

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Sucrose
Esters
Carbon
Bactericides
Pathogens
Cytotoxicity
Anti-Infective Agents
Liver
Libraries
Toxicity
Hepatocellular Carcinoma
Bacteria
Breast
Cells
Impurities
Cell Line
Food
Lung

Keywords

  • Antibacterial activity
  • Antifungal activity
  • Cytotoxic activity
  • Sucrose
  • Unsaturated esters

Cite this

Petrova, Krasimira T. ; Barros, M. Teresa ; Calhelha, Ricardo C. ; Soković, Marina ; Ferreira, Isabel C.F.R. / Antimicrobial and cytotoxic activities of short carbon chain unsaturated sucrose esters. In: Medicinal Chemistry Research. 2018 ; Vol. 27, No. 3. pp. 980-988.
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Antimicrobial and cytotoxic activities of short carbon chain unsaturated sucrose esters. / Petrova, Krasimira T.; Barros, M. Teresa; Calhelha, Ricardo C.; Soković, Marina; Ferreira, Isabel C.F.R.

In: Medicinal Chemistry Research, Vol. 27, No. 3, 01.03.2018, p. 980-988.

Research output: Contribution to journalArticle

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