TY - JOUR
T1 - Antimicrobial activity of quinoxaline 1,4-dioxide with 2- and 3- substituted derivatives
AU - Vieira, Mónica A. A.
AU - Pinheiro, Catia
AU - Fernandes, Ruben M.
AU - Noronha, João Paulo da Costa de
AU - Prudêncio, Cristina
PY - 2014/4
Y1 - 2014/4
N2 - Quinoxaline is a chemical compound that presents a structure that is similar to quinolone antibiotics. The present work reports the study of the antimicrobial activity of quinoxalineN,N-dioxide and some derivatives against bacterial and yeast strains. The compounds studied were quinoxaline-1,4-dioxide (QNX), 2-methylquinoxaline-1,4-dioxide (2MQNX), 2-methyl-3-benzoylquinoxaline-1,4-dioxide (2M3BenzoylQNX), 2-methyl-3-benzylquinoxaline-1,4-dioxide (2M3BQNX), 2-amino-3-cyanoquinoxaline-1,4-dioxide (2A3CQNX), 3-methyl-2-quinoxalinecarboxamide-1,4-dioxide (3M2QNXC), 2-hydroxyphenazine-N,N-dioxide (2HF) and 3-methyl-N-(2-methylphenyl)quinoxalinecarboxamide-1,4-dioxide (3MN(2MF)QNXC). The prokaryotic strains used wereStaphylococcus aureusATCC 6538,S. aureusATCC 6538P,S. aureusATCC 29213,Escherichia coliATCC 25922,E. coliS3R9,E. coliS3R22,E. coliTEM-1 CTX-M9,E. coliTEM-1,E. coliAmpC Mox-2,E. coliCTX-M2 eE. coliCTX-M9. TheCandida albicansATCC 10231 andSaccharomyces cerevisiaePYCC 4072 were used as eukaryotic strains. For the compounds that presented activity using the disk diffusion method, the minimum inhibitory concentration (MIC) was determined. The alterations of cellular viability were evaluated in a time-course assay. Death curves for bacteria and growth curves forS. cerevisiaePYCC 4072 were also accessed. The results obtained suggest potential new drugs for antimicrobial activity chemotherapy since the MIC's determined present low values and cellular viability tests show the complete elimination of the bacterial strain. Also, the cellular viability tests for the eukaryotic model,S. cerevisiae, indicate low toxicity for the compounds tested.
AB - Quinoxaline is a chemical compound that presents a structure that is similar to quinolone antibiotics. The present work reports the study of the antimicrobial activity of quinoxalineN,N-dioxide and some derivatives against bacterial and yeast strains. The compounds studied were quinoxaline-1,4-dioxide (QNX), 2-methylquinoxaline-1,4-dioxide (2MQNX), 2-methyl-3-benzoylquinoxaline-1,4-dioxide (2M3BenzoylQNX), 2-methyl-3-benzylquinoxaline-1,4-dioxide (2M3BQNX), 2-amino-3-cyanoquinoxaline-1,4-dioxide (2A3CQNX), 3-methyl-2-quinoxalinecarboxamide-1,4-dioxide (3M2QNXC), 2-hydroxyphenazine-N,N-dioxide (2HF) and 3-methyl-N-(2-methylphenyl)quinoxalinecarboxamide-1,4-dioxide (3MN(2MF)QNXC). The prokaryotic strains used wereStaphylococcus aureusATCC 6538,S. aureusATCC 6538P,S. aureusATCC 29213,Escherichia coliATCC 25922,E. coliS3R9,E. coliS3R22,E. coliTEM-1 CTX-M9,E. coliTEM-1,E. coliAmpC Mox-2,E. coliCTX-M2 eE. coliCTX-M9. TheCandida albicansATCC 10231 andSaccharomyces cerevisiaePYCC 4072 were used as eukaryotic strains. For the compounds that presented activity using the disk diffusion method, the minimum inhibitory concentration (MIC) was determined. The alterations of cellular viability were evaluated in a time-course assay. Death curves for bacteria and growth curves forS. cerevisiaePYCC 4072 were also accessed. The results obtained suggest potential new drugs for antimicrobial activity chemotherapy since the MIC's determined present low values and cellular viability tests show the complete elimination of the bacterial strain. Also, the cellular viability tests for the eukaryotic model,S. cerevisiae, indicate low toxicity for the compounds tested.
KW - Antimicrobial activity
KW - Quinoxaline N,N-dioxide derivatives
KW - Cellular viability
KW - Minimum inhibitory concentration
KW - Antimicrobial activity
KW - Cellular viability
KW - Minimum inhibitory concentration
KW - Quinoxaline N,N-dioxide derivatives
U2 - 10.1016/j.micres.2013.06.015
DO - 10.1016/j.micres.2013.06.015
M3 - Article
C2 - 23928379
SN - 0944-5013
VL - 169
SP - 287
EP - 293
JO - Microbiological Research
JF - Microbiological Research
IS - 4
ER -