Antimalarial flavonol glycosides from Euphorbia hirta

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Bioassay-guided fractionation of the MeOH extracts of Euphorbia hirta Linn (Euphorbiaceae) aerial parts led to the isolation of flavonol glycosides afzelin (1), quercitrin (2), and myricitrin (3), whose structures were established by MS and NMR analysis. Compounds 1-3 showed proliferation inhibition of Plasmodium falciparum, with IC(50) values of 1.1, 4.1, 5.4 mu g/mL, repectively. On the other hand, they exhibited little cytotoxic property against human epidermoid carcinoma KB 3-1 cells.
Original languageUnknown
Pages (from-to)278-281
JournalPharmaceutical Biology
Volume45
Issue number4
DOIs
Publication statusPublished - 1 Jan 2007

Cite this

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title = "Antimalarial flavonol glycosides from Euphorbia hirta",
abstract = "Bioassay-guided fractionation of the MeOH extracts of Euphorbia hirta Linn (Euphorbiaceae) aerial parts led to the isolation of flavonol glycosides afzelin (1), quercitrin (2), and myricitrin (3), whose structures were established by MS and NMR analysis. Compounds 1-3 showed proliferation inhibition of Plasmodium falciparum, with IC(50) values of 1.1, 4.1, 5.4 mu g/mL, repectively. On the other hand, they exhibited little cytotoxic property against human epidermoid carcinoma KB 3-1 cells.",
author = "Abreu, {Pedro Jorge Macedo de}",
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Antimalarial flavonol glycosides from Euphorbia hirta. / Abreu, Pedro Jorge Macedo de.

In: Pharmaceutical Biology, Vol. 45, No. 4, 01.01.2007, p. 278-281.

Research output: Contribution to journalArticle

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AU - Abreu, Pedro Jorge Macedo de

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AB - Bioassay-guided fractionation of the MeOH extracts of Euphorbia hirta Linn (Euphorbiaceae) aerial parts led to the isolation of flavonol glycosides afzelin (1), quercitrin (2), and myricitrin (3), whose structures were established by MS and NMR analysis. Compounds 1-3 showed proliferation inhibition of Plasmodium falciparum, with IC(50) values of 1.1, 4.1, 5.4 mu g/mL, repectively. On the other hand, they exhibited little cytotoxic property against human epidermoid carcinoma KB 3-1 cells.

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DO - 10.1080/13880200701214748

M3 - Article

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JO - Pharmaceutical Biology

JF - Pharmaceutical Biology

SN - 1388-0209

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