Antimalarial flavonol glycosides from Euphorbia hirta

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Abstract

Bioassay-guided fractionation of the MeOH extracts of Euphorbia hirta Linn (Euphorbiaceae) aerial parts led to the isolation of flavonol glycosides afzelin (1), quercitrin (2), and myricitrin (3), whose structures were established by MS and NMR analysis. Compounds 1-3 showed proliferation inhibition of Plasmodium falciparum, with IC(50) values of 1.1, 4.1, 5.4 mu g/mL, repectively. On the other hand, they exhibited little cytotoxic property against human epidermoid carcinoma KB 3-1 cells.
Original languageUnknown
Pages (from-to)278-281
JournalPharmaceutical Biology
Volume45
Issue number4
DOIs
Publication statusPublished - 1 Jan 2007

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