TY - JOUR
T1 - Antifungal Potential of Marine Organisms of the Yucatan Peninsula (Mexico) against Medically Important Candida spp.
AU - Pech-Puch, Dawrin
AU - Grilo, Diana
AU - Calva-Pérez, Susana Eunice
AU - Pedras, Andreia
AU - Villegas-Hernández, Harold
AU - Guillén-Hernández, Sergio
AU - Díaz-Gamboa, Raúl
AU - Tunjano, Mateo Forero
AU - Rodríguez, Jaime
AU - Lenis-Rojas, Oscar A.
AU - Jiménez, Carlos
AU - Pimentel, Catarina
N1 - Funding Information:
The authors acknowledge the Fundação para a Ciência e a Tecnologia, I.P., through (i) MOSTMICRO-ITQB R&D Unit (UIDB/04612/2020), (ii) LS4FUTURE Associated Laboratory (LA/P/0087/2020), (iii) POPH (Programa Operacional Potencial Humano), and FSE (European Social Fund) CEEC 2017 Initiative (to O.A.L.-R.) and (iv) PhD fellowship to A.P. (SFRH/BD/148854/2019). D.P.-P was the recipient of a postdoctoral fellowship from the National Council of Science and Technology (CONACYT) of Mexico.
Publisher Copyright:
© 2023 by the authors.
PY - 2023/1
Y1 - 2023/1
N2 - Invasive fungal infections represent a global health threat. They are associated with high mortality and morbidity rates, partly due to the ineffectiveness of the available antifungal agents. The rampant increase in infections recalcitrant to the current antifungals has worsened this scenario and made the discovery of new and more effective antifungals a pressing health issue. In this study, 65 extracts from marine organisms of the Yucatan Peninsula, Mexico, were screened for antifungal activity against Candida albicans and Candida glabrata, two of the most prevalent fungal species that cause nosocomial invasive fungal infections worldwide. A total of 51 sponges, 13 ascidians and 1 gorgonian were collected from the coral reef and mangrove forest in the Yucatan Peninsula (Mexico) and extracted with organic solvents. Nine crude extracts showed potent antifungal activity, of which four extracts from the sponge species Aiolochroia crassa, Amphimedon compressa, Monanchora arbuscula and Agelas citrina had promising activity against Candida spp. Bioassay-guided fractionation of the M. arbuscula extract revealed the remarkable fungicidal activity of some fractions. Analysis of the chemical composition of one of the most active fractions by UHPLC-HRMS and NMR indicated the presence of mirabilin B and penaresidin B, and their contribution to the observed antifungal activity is discussed. Overall, this work highlights marine organisms of the Yucatan Peninsula as important reservoirs of natural products with promising fungicidal activity, which may greatly advance the treatment of invasive fungal infections, especially those afflicting immunosuppressed patients.
AB - Invasive fungal infections represent a global health threat. They are associated with high mortality and morbidity rates, partly due to the ineffectiveness of the available antifungal agents. The rampant increase in infections recalcitrant to the current antifungals has worsened this scenario and made the discovery of new and more effective antifungals a pressing health issue. In this study, 65 extracts from marine organisms of the Yucatan Peninsula, Mexico, were screened for antifungal activity against Candida albicans and Candida glabrata, two of the most prevalent fungal species that cause nosocomial invasive fungal infections worldwide. A total of 51 sponges, 13 ascidians and 1 gorgonian were collected from the coral reef and mangrove forest in the Yucatan Peninsula (Mexico) and extracted with organic solvents. Nine crude extracts showed potent antifungal activity, of which four extracts from the sponge species Aiolochroia crassa, Amphimedon compressa, Monanchora arbuscula and Agelas citrina had promising activity against Candida spp. Bioassay-guided fractionation of the M. arbuscula extract revealed the remarkable fungicidal activity of some fractions. Analysis of the chemical composition of one of the most active fractions by UHPLC-HRMS and NMR indicated the presence of mirabilin B and penaresidin B, and their contribution to the observed antifungal activity is discussed. Overall, this work highlights marine organisms of the Yucatan Peninsula as important reservoirs of natural products with promising fungicidal activity, which may greatly advance the treatment of invasive fungal infections, especially those afflicting immunosuppressed patients.
KW - antifungal
KW - Candida
KW - marine natural products
KW - Yucatan Peninsula
UR - http://www.scopus.com/inward/record.url?scp=85146826370&partnerID=8YFLogxK
U2 - 10.3390/molecules28020606
DO - 10.3390/molecules28020606
M3 - Article
C2 - 36677663
AN - SCOPUS:85146826370
SN - 1420-3049
VL - 28
JO - Molecules
JF - Molecules
IS - 2
M1 - 606
ER -
