Antibody Response to Toscana Virus and Sandfly Fever Sicilian Virus in Cats Naturally Exposed to Phlebotomine Sand Fly Bites in Portugal

André Pereira, Nazli Ayhan, JM Cristovao, Vilhena, Hugo C.R, Ângela Martins, Patrícia Cachola, Henriques, Joaquim JGP, Mónica Coimbra, Catarino, Ana Lúcia, Tereza Lestinova, Tatiana Spitzova, Petr Volf, L Campino, Charrel, Rémi Nicolas, C Maia

Research output: Contribution to journalArticle

Abstract

Phlebotomine sand fly-borne pathogens such as Leishmania spp. and phleboviruses are emerging threats to humans and animals worldwide. The aim of this work was to evaluate the exposure of cats from Portugal to Toscana virus (TOSV) and Sandfly Fever Sicilian virus (SFSV) and assess the associated risk factors. The possible association between exposure to Phlebotomus perniciosus saliva with TOSV and SFSV was also investigated. Out of 369 cats tested, 18 (4.9%, n = 365) were seropositive for TOSV, and eight (2.2%, n = 367) were seropositive for SFSV. Multivariate logistic regression analysis showed that cats presenting clinical signs that were compatible with leishmaniosis and antibodies to TOSV had a significantly higher risk of being SFSV seropositive. The presence of antibodies to sand fly-borne viruses in cats indicate that these animals are frequently exposed to sand flies and transmitted pathogens. Data suggest that cats can be used to qualitatively monitor human exposure to TOSV and SFSV in endemic areas. The clinical impact of SFSV in cats' health should be investigated. The identification of the sand fly species responsible for the circulation of TOSV and SFSV in nature and the evaluation of the vectorial competence of P. perniciosus to SFSV should also be addressed.

Original languageEnglish
Article number339
Pages (from-to)339-347
Number of pages8
JournalMicroorganisms
VolumeVol. 7
Issue numbern.º 9
DOIs
Publication statusPublished - 11 Sep 2019

Keywords

  • Bunyavirales
  • Phenuiviridae
  • Phlebotomus perniciosus
  • Phlebovirus
  • Sandfly Fever Sicilian Virus
  • Toscana virus
  • Arbovirus
  • Cat
  • Saliva

Fingerprint Dive into the research topics of 'Antibody Response to Toscana Virus and Sandfly Fever Sicilian Virus in Cats Naturally Exposed to Phlebotomine Sand Fly Bites in Portugal'. Together they form a unique fingerprint.

  • Cite this

    Pereira, A., Ayhan, N., Cristovao, JM., Hugo C.R, V., Martins, Â., Cachola, P., Joaquim JGP, H., Coimbra, M., Ana Lúcia, C., Lestinova, T., Spitzova, T., Volf, P., Campino, L., Rémi Nicolas, C., & Maia, C. (2019). Antibody Response to Toscana Virus and Sandfly Fever Sicilian Virus in Cats Naturally Exposed to Phlebotomine Sand Fly Bites in Portugal. Microorganisms, Vol. 7(n.º 9), 339-347. [339]. https://doi.org/10.3390/microorganisms7090339