Antibiotics and extracorporeal circulation - one size does not fit all

João Gonçalves Pereira, Bruno Oliveira

Research output: Contribution to journalBook/Film/Article review

4 Citations (Scopus)
1 Downloads (Pure)

Abstract

Dosing of antibiotics in critically ill patients is a significant challenge. The increasing number of patients undergoing extracorporeal membrane oxygenation further complicates the issue due to inflammatory activation and to drug sequestration in the circuit. Since patients receiving extracorporeal membrane oxygenation commonly face severe infections, appropriate antibiotic selection and correct dosing is of paramount importance to improve survival. Therapeutic drug monitoring (whenever available) or population pharmacokinetics, based on readily available clinical and laboratory data, should help tailor antibiotic dosing to the individual patient.
Original languageEnglish
Article number695
Pages (from-to)Online
Number of pages12
JournalCritical Care
Volume18
Issue number6
DOIs
Publication statusPublished - 19 Dec 2014

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