TY - JOUR
T1 - Antibiotic resistance as a stress response
T2 - Recovery of high-level oxacillin resistance in methicillin-resistant Staphylococcus aureus “auxiliary” (fem) mutants by induction of the stringent stress response
AU - Kim, Choon Keun
AU - Milheiriço, Catarina
AU - De Lencastre, Hermínia
AU - Tomasza, Alexander
PY - 2017/8/1
Y1 - 2017/8/1
N2 - Studies with methicillin-resistant Staphylococcus aureus (MRSA) strain COL have shown that the optimal resistance phenotype requires not only mecA but also a large number of “auxiliary genes” identified by Tn551 mutagenesis. The majority of auxiliary mutants showed greatly increased levels of oxacillin resistance when grown in the presence of sub-MICs of mupirocin, suggesting that the mechanism of reduced resistance in the auxiliary mutants involved the interruption of a stringent stress response, causing reduced production of penicillin-binding protein 2A (PBP 2A).
AB - Studies with methicillin-resistant Staphylococcus aureus (MRSA) strain COL have shown that the optimal resistance phenotype requires not only mecA but also a large number of “auxiliary genes” identified by Tn551 mutagenesis. The majority of auxiliary mutants showed greatly increased levels of oxacillin resistance when grown in the presence of sub-MICs of mupirocin, suggesting that the mechanism of reduced resistance in the auxiliary mutants involved the interruption of a stringent stress response, causing reduced production of penicillin-binding protein 2A (PBP 2A).
KW - Auxiliary genes
KW - Oxacillin resistance expression
KW - Stress response
UR - http://www.scopus.com/inward/record.url?scp=85026408601&partnerID=8YFLogxK
U2 - 10.1128/AAC.00313-17
DO - 10.1128/AAC.00313-17
M3 - Article
C2 - 28630179
AN - SCOPUS:85026408601
SN - 0066-4804
VL - 61
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 8
M1 - e00313
ER -
