TY - JOUR
T1 - Antibacterial properties of compounds isolated from Carpobrotus edulis.
AU - Martins, Ana
AU - Vasas, A.
AU - Bettencourt, Miguel Viveiros
AU - Molnár , J
AU - Hohmann, J.
AU - Amaral, Leonard
PY - 2011/1/1
Y1 - 2011/1/1
N2 - Several compounds isolated from the plant Carpobrotus edulis were evaluated for their activity against multidrug-resistant (MDR) bacteria and their efflux pump systems. Amongst the compounds isolated, six compounds were tested, namely uvaol, -amyrin, oleanolic acid, catechin, epicatechin and monogalactosyldiacylglycerol. Oleanolic acid presented high antibacterial activity against a large number of bacterial strains. The triterpene uvaol was the most active compound for modulation of efflux activity by MDR Gram-positive strains.
AB - Several compounds isolated from the plant Carpobrotus edulis were evaluated for their activity against multidrug-resistant (MDR) bacteria and their efflux pump systems. Amongst the compounds isolated, six compounds were tested, namely uvaol, -amyrin, oleanolic acid, catechin, epicatechin and monogalactosyldiacylglycerol. Oleanolic acid presented high antibacterial activity against a large number of bacterial strains. The triterpene uvaol was the most active compound for modulation of efflux activity by MDR Gram-positive strains.
KW - Efflux pumps
KW - Escherichia coli
KW - Mycobacterium tuberculosis
KW - Efflux pump inhibition
KW - Multidrug resistance
KW - Salmonella enterica serotype Enteritidis
KW - Staphylococcus aureus
KW - Isolated compounds
KW - Enterococcus faecalis
KW - Aizoaceae
KW - Carpobrotus edulis
U2 - 10.1016/j.ijantimicag.2011.01.016
DO - 10.1016/j.ijantimicag.2011.01.016
M3 - Article
VL - 37
SP - 438
EP - 444
JO - International Journal Of Antimicrobial Agents
JF - International Journal Of Antimicrobial Agents
SN - 0924-8579
IS - 5
ER -
