Antibacterial activity of Ionic Liquids based on ampicillin against resistant bacteria

Ricardo Ferraz; Vania Teixeira; Debora Rodrigues; Ruben M. Fernandes; Cristina Prudêncio; João Paulo da Costa de Noronha; Zeljko Petrovski; Luís Alexandre Almeida Fernandes Cobra Branco

doi:10.1039/C3RA44286A

Antibacterial activity of Ionic Liquids based on ampicillin against resistant bacteria

Ricardo Ferraz, Vania Teixeira, Debora Rodrigues, Ruben M. Fernandes, Cristina Prudêncio, João Paulo da Costa de Noronha, Zeljko Petrovski, Luís Alexandre Almeida Fernandes Cobra Branco

Research output: Contribution to journal › Article › peer-review

89 Citations (Scopus)

Abstract

Antibacterial activities of novel Active Pharmaceutical Ingredient Ionic Liquids (API–ILs) based on ampicillin anion [Amp] have been evaluated. They showed growth inhibition and bactericidal properties on some sensitive bacteria and especially some Gram-negative resistant bacteria when compared to the [Na][Amp] and the initial bromide and chloride salts. For these studies were analysed the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBIC) against sensitive Gram-negative bacteriaEscherichia coliATCC 25922 andKlebsiella pneumoniae(clinically isolated), as well as sensitive Gram positiveStaphylococcus AureusATCC 25923,Staphylococcus epidermidisandEnterococcus faecalisand completed using clinically isolated resistent strains such asE. coliTEM CTX M9,E. coliCTX M2 andE. coliAmpC MOX. From the obtained MIC values of studied API–ILs and standard [Na][Amp] were derived RDIC values (relative decrease of inhibitory concentration). High RDIC values of [C16Pyr][Amp] especially against two resistant Gram-negative strainsE. coliTEM CTX M9 (RDIC >1000) andE. coliCTX M2 (RDIC >100) point clearly to a potential promising role of API–ILs as antimicrobial drugs in particular against resistant bacterial strains.

Original language	English
Pages (from-to)	4301-4307
Journal	RSC Advances
Volume	4
Issue number	9
DOIs	https://doi.org/10.1039/C3RA44286A
Publication status	Published - 2014

Keywords

Active pharmaceutical ingredients
Anti-bacterial activity
Bactericidal properties
Gram-negative bacteria
Inhibitory concentration
Minimum bactericidal concentrations
Minimum inhibitory concentration
Staphylococcus epidermidis

Access to Document

10.1039/C3RA44286A

Cite this

@article{862cf6f3296a467dba2f62eb6ae80b6b,

title = "Antibacterial activity of Ionic Liquids based on ampicillin against resistant bacteria",

abstract = "Antibacterial activities of novel Active Pharmaceutical Ingredient Ionic Liquids (API–ILs) based on ampicillin anion [Amp] have been evaluated. They showed growth inhibition and bactericidal properties on some sensitive bacteria and especially some Gram-negative resistant bacteria when compared to the [Na][Amp] and the initial bromide and chloride salts. For these studies were analysed the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBIC) against sensitive Gram-negative bacteriaEscherichia coliATCC 25922 andKlebsiella pneumoniae(clinically isolated), as well as sensitive Gram positiveStaphylococcus AureusATCC 25923,Staphylococcus epidermidisandEnterococcus faecalisand completed using clinically isolated resistent strains such asE. coliTEM CTX M9,E. coliCTX M2 andE. coliAmpC MOX. From the obtained MIC values of studied API–ILs and standard [Na][Amp] were derived RDIC values (relative decrease of inhibitory concentration). High RDIC values of [C16Pyr][Amp] especially against two resistant Gram-negative strainsE. coliTEM CTX M9 (RDIC >1000) andE. coliCTX M2 (RDIC >100) point clearly to a potential promising role of API–ILs as antimicrobial drugs in particular against resistant bacterial strains.",

keywords = "Active pharmaceutical ingredients, Anti-bacterial activity, Bactericidal properties, Gram-negative bacteria, Inhibitory concentration, Minimum bactericidal concentrations, Minimum inhibitory concentration, Staphylococcus epidermidis",

author = "Ricardo Ferraz and Vania Teixeira and Debora Rodrigues and Fernandes, {Ruben M.} and Cristina Prud{\^e}ncio and Noronha, {Jo{\~a}o Paulo da Costa de} and Zeljko Petrovski and Branco, {Lu{\'i}s Alexandre Almeida Fernandes Cobra}",

note = "SCOPUSID:84891447855 WOS:000328956700014",

year = "2014",

doi = "10.1039/C3RA44286A",

language = "English",

volume = "4",

pages = "4301--4307",

journal = "RSC Advances",

issn = "2046-2069",

publisher = "RSC - Royal Society of Chemistry",

number = "9",

}

TY - JOUR

T1 - Antibacterial activity of Ionic Liquids based on ampicillin against resistant bacteria

AU - Ferraz, Ricardo

AU - Teixeira, Vania

AU - Rodrigues, Debora

AU - Fernandes, Ruben M.

AU - Prudêncio, Cristina

AU - Noronha, João Paulo da Costa de

AU - Petrovski, Zeljko

AU - Branco, Luís Alexandre Almeida Fernandes Cobra

N1 - SCOPUSID:84891447855 WOS:000328956700014

PY - 2014

Y1 - 2014

N2 - Antibacterial activities of novel Active Pharmaceutical Ingredient Ionic Liquids (API–ILs) based on ampicillin anion [Amp] have been evaluated. They showed growth inhibition and bactericidal properties on some sensitive bacteria and especially some Gram-negative resistant bacteria when compared to the [Na][Amp] and the initial bromide and chloride salts. For these studies were analysed the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBIC) against sensitive Gram-negative bacteriaEscherichia coliATCC 25922 andKlebsiella pneumoniae(clinically isolated), as well as sensitive Gram positiveStaphylococcus AureusATCC 25923,Staphylococcus epidermidisandEnterococcus faecalisand completed using clinically isolated resistent strains such asE. coliTEM CTX M9,E. coliCTX M2 andE. coliAmpC MOX. From the obtained MIC values of studied API–ILs and standard [Na][Amp] were derived RDIC values (relative decrease of inhibitory concentration). High RDIC values of [C16Pyr][Amp] especially against two resistant Gram-negative strainsE. coliTEM CTX M9 (RDIC >1000) andE. coliCTX M2 (RDIC >100) point clearly to a potential promising role of API–ILs as antimicrobial drugs in particular against resistant bacterial strains.

AB - Antibacterial activities of novel Active Pharmaceutical Ingredient Ionic Liquids (API–ILs) based on ampicillin anion [Amp] have been evaluated. They showed growth inhibition and bactericidal properties on some sensitive bacteria and especially some Gram-negative resistant bacteria when compared to the [Na][Amp] and the initial bromide and chloride salts. For these studies were analysed the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBIC) against sensitive Gram-negative bacteriaEscherichia coliATCC 25922 andKlebsiella pneumoniae(clinically isolated), as well as sensitive Gram positiveStaphylococcus AureusATCC 25923,Staphylococcus epidermidisandEnterococcus faecalisand completed using clinically isolated resistent strains such asE. coliTEM CTX M9,E. coliCTX M2 andE. coliAmpC MOX. From the obtained MIC values of studied API–ILs and standard [Na][Amp] were derived RDIC values (relative decrease of inhibitory concentration). High RDIC values of [C16Pyr][Amp] especially against two resistant Gram-negative strainsE. coliTEM CTX M9 (RDIC >1000) andE. coliCTX M2 (RDIC >100) point clearly to a potential promising role of API–ILs as antimicrobial drugs in particular against resistant bacterial strains.

KW - Active pharmaceutical ingredients

KW - Anti-bacterial activity

KW - Bactericidal properties

KW - Gram-negative bacteria

KW - Inhibitory concentration

KW - Minimum bactericidal concentrations

KW - Minimum inhibitory concentration

KW - Staphylococcus epidermidis

U2 - 10.1039/C3RA44286A

DO - 10.1039/C3RA44286A

M3 - Article

SN - 2046-2069

VL - 4

SP - 4301

EP - 4307

JO - RSC Advances

JF - RSC Advances

IS - 9

ER -

Antibacterial activity of Ionic Liquids based on ampicillin against resistant bacteria

Abstract

Keywords

Access to Document

Fingerprint

Cite this