Antibacterial activity of Ionic Liquids based on ampicillin against resistant bacteria

Ricardo Ferraz, Vania Teixeira, Debora Rodrigues, Ruben M. Fernandes, Cristina Prudêncio, João Paulo da Costa de Noronha, Zeljko Petrovski, Luís Alexandre Almeida Fernandes Cobra Branco

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47 Citations (Scopus)

Abstract

Antibacterial activities of novel Active Pharmaceutical Ingredient Ionic Liquids (API–ILs) based on ampicillin anion [Amp] have been evaluated. They showed growth inhibition and bactericidal properties on some sensitive bacteria and especially some Gram-negative resistant bacteria when compared to the [Na][Amp] and the initial bromide and chloride salts. For these studies were analysed the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBIC) against sensitive Gram-negative bacteriaEscherichia coliATCC 25922 andKlebsiella pneumoniae(clinically isolated), as well as sensitive Gram positiveStaphylococcus AureusATCC 25923,Staphylococcus epidermidisandEnterococcus faecalisand completed using clinically isolated resistent strains such asE. coliTEM CTX M9,E. coliCTX M2 andE. coliAmpC MOX. From the obtained MIC values of studied API–ILs and standard [Na][Amp] were derived RDIC values (relative decrease of inhibitory concentration). High RDIC values of [C16Pyr][Amp] especially against two resistant Gram-negative strainsE. coliTEM CTX M9 (RDIC >1000) andE. coliCTX M2 (RDIC >100) point clearly to a potential promising role of API–ILs as antimicrobial drugs in particular against resistant bacterial strains.
Original languageEnglish
Pages (from-to)4301-4307
JournalRSC Advances
Volume4
Issue number9
DOIs
Publication statusPublished - 2014

Keywords

  • Active pharmaceutical ingredients
  • Anti-bacterial activity
  • Bactericidal properties
  • Gram-negative bacteria
  • Inhibitory concentration
  • Minimum bactericidal concentrations
  • Minimum inhibitory concentration
  • Staphylococcus epidermidis

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