Anti-cyclic citrullinated peptide antibodies and rheumatoid factor in Sjögren's syndrome

Filipe Barcelos, Isabel Abreu, José Vaz Patto, Helder Trindade, Ana Teixeira

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Abstract

Objectives: The purpose of this study was to evaluate the prevalence and clinical significance of anti-cyclic citrullinated peptide antibodies (anti-CCP-Abs), IgM and IgA rheumatoid factors (RFs) in primary Sjogren's Syndrome (pSS). Materials and Methods:We compared clinical and serological. characteristics of 31 pSS and 31 Rheumatoid Arthritis (RA) patients. Both, anti-CCP-Abs and RFs (IgM, IgA) directed against Fc determinants of IgG from humans and rabbit were detected by enzyme-linked immunosorbent assay (ELISA). We included 31 blood donors as control group for the evaluation of RFs and anti-CCP-Abs. Nine (29%) pSS patients presented arthritis, and 10 (32,3%) RA patients also had secondary Sjogren's syndrome (sSS) Results: IgM and IgA RFs prevalence was similar in pSS and RA, whichever the antigene (Human or Rabbit IgG) used. However, RA patients with sSS showed a tendency to present more often RF positivity, longer disease duration and higher ESR and CRP when compared with pSS patients with arthritis. Anti-CCP-Abs were detected in 64,5% of RA patients and in only 6,9% of pSS patients (p<0,0005). Anti-CCP-Abs were more often positive in RA patients with sSS (RA/sSS) (8 patients, 80%) than in RA patients without sSS (18 patients, 58,1%), and were absent in pSS patients with arthritis. RF-positive pSS patients presented more often pulmonary involvement and higher inflammatory parameters, and less often neuropathy compared to RF-negative patients. In controls, anti-CCP-Abs were absent and REs were negligible. Conclusions: Anti-CCP-Abs were detected in only a few pSS patients, none of whom presented arthritis, which contrasts with the high frequency of these antibodies in RA/sSS. These results suggest that anti-CCP-Abs could be useful in the distinction between pSS and RA with sSS. Although not useful for the differential diagnosis between RA and pSS, RFs may have a prognostic role in pSS.
Original languageEnglish
Pages (from-to)608-612
Number of pages5
JournalActa reumatologica portuguesa
Volume34
Issue number4
Publication statusPublished - Oct 2009

Fingerprint

Rheumatoid Factor
Sjogren's Syndrome
Antibodies
Rheumatoid Arthritis
Arthritis
Immunoglobulin A
cyclic citrullinated peptide
Immunoglobulin M
Immunoglobulin G
Rabbits

Keywords

  • Sjögren’s Syndrome
  • Anti-CCP Antibodies
  • Rheumatoid Factors
  • Rheumatoid Arthritis

Cite this

@article{6b3f7ece660442378453de425299d0cb,
title = "Anti-cyclic citrullinated peptide antibodies and rheumatoid factor in Sj{\"o}gren's syndrome",
abstract = "Objectives: The purpose of this study was to evaluate the prevalence and clinical significance of anti-cyclic citrullinated peptide antibodies (anti-CCP-Abs), IgM and IgA rheumatoid factors (RFs) in primary Sjogren's Syndrome (pSS). Materials and Methods:We compared clinical and serological. characteristics of 31 pSS and 31 Rheumatoid Arthritis (RA) patients. Both, anti-CCP-Abs and RFs (IgM, IgA) directed against Fc determinants of IgG from humans and rabbit were detected by enzyme-linked immunosorbent assay (ELISA). We included 31 blood donors as control group for the evaluation of RFs and anti-CCP-Abs. Nine (29{\%}) pSS patients presented arthritis, and 10 (32,3{\%}) RA patients also had secondary Sjogren's syndrome (sSS) Results: IgM and IgA RFs prevalence was similar in pSS and RA, whichever the antigene (Human or Rabbit IgG) used. However, RA patients with sSS showed a tendency to present more often RF positivity, longer disease duration and higher ESR and CRP when compared with pSS patients with arthritis. Anti-CCP-Abs were detected in 64,5{\%} of RA patients and in only 6,9{\%} of pSS patients (p<0,0005). Anti-CCP-Abs were more often positive in RA patients with sSS (RA/sSS) (8 patients, 80{\%}) than in RA patients without sSS (18 patients, 58,1{\%}), and were absent in pSS patients with arthritis. RF-positive pSS patients presented more often pulmonary involvement and higher inflammatory parameters, and less often neuropathy compared to RF-negative patients. In controls, anti-CCP-Abs were absent and REs were negligible. Conclusions: Anti-CCP-Abs were detected in only a few pSS patients, none of whom presented arthritis, which contrasts with the high frequency of these antibodies in RA/sSS. These results suggest that anti-CCP-Abs could be useful in the distinction between pSS and RA with sSS. Although not useful for the differential diagnosis between RA and pSS, RFs may have a prognostic role in pSS.",
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author = "Filipe Barcelos and Isabel Abreu and Patto, {Jos{\'e} Vaz} and Helder Trindade and Ana Teixeira",
year = "2009",
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Anti-cyclic citrullinated peptide antibodies and rheumatoid factor in Sjögren's syndrome. / Barcelos, Filipe; Abreu, Isabel; Patto, José Vaz; Trindade, Helder ; Teixeira, Ana.

In: Acta reumatologica portuguesa, Vol. 34, No. 4, 10.2009, p. 608-612.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Anti-cyclic citrullinated peptide antibodies and rheumatoid factor in Sjögren's syndrome

AU - Barcelos, Filipe

AU - Abreu, Isabel

AU - Patto, José Vaz

AU - Trindade, Helder

AU - Teixeira, Ana

PY - 2009/10

Y1 - 2009/10

N2 - Objectives: The purpose of this study was to evaluate the prevalence and clinical significance of anti-cyclic citrullinated peptide antibodies (anti-CCP-Abs), IgM and IgA rheumatoid factors (RFs) in primary Sjogren's Syndrome (pSS). Materials and Methods:We compared clinical and serological. characteristics of 31 pSS and 31 Rheumatoid Arthritis (RA) patients. Both, anti-CCP-Abs and RFs (IgM, IgA) directed against Fc determinants of IgG from humans and rabbit were detected by enzyme-linked immunosorbent assay (ELISA). We included 31 blood donors as control group for the evaluation of RFs and anti-CCP-Abs. Nine (29%) pSS patients presented arthritis, and 10 (32,3%) RA patients also had secondary Sjogren's syndrome (sSS) Results: IgM and IgA RFs prevalence was similar in pSS and RA, whichever the antigene (Human or Rabbit IgG) used. However, RA patients with sSS showed a tendency to present more often RF positivity, longer disease duration and higher ESR and CRP when compared with pSS patients with arthritis. Anti-CCP-Abs were detected in 64,5% of RA patients and in only 6,9% of pSS patients (p<0,0005). Anti-CCP-Abs were more often positive in RA patients with sSS (RA/sSS) (8 patients, 80%) than in RA patients without sSS (18 patients, 58,1%), and were absent in pSS patients with arthritis. RF-positive pSS patients presented more often pulmonary involvement and higher inflammatory parameters, and less often neuropathy compared to RF-negative patients. In controls, anti-CCP-Abs were absent and REs were negligible. Conclusions: Anti-CCP-Abs were detected in only a few pSS patients, none of whom presented arthritis, which contrasts with the high frequency of these antibodies in RA/sSS. These results suggest that anti-CCP-Abs could be useful in the distinction between pSS and RA with sSS. Although not useful for the differential diagnosis between RA and pSS, RFs may have a prognostic role in pSS.

AB - Objectives: The purpose of this study was to evaluate the prevalence and clinical significance of anti-cyclic citrullinated peptide antibodies (anti-CCP-Abs), IgM and IgA rheumatoid factors (RFs) in primary Sjogren's Syndrome (pSS). Materials and Methods:We compared clinical and serological. characteristics of 31 pSS and 31 Rheumatoid Arthritis (RA) patients. Both, anti-CCP-Abs and RFs (IgM, IgA) directed against Fc determinants of IgG from humans and rabbit were detected by enzyme-linked immunosorbent assay (ELISA). We included 31 blood donors as control group for the evaluation of RFs and anti-CCP-Abs. Nine (29%) pSS patients presented arthritis, and 10 (32,3%) RA patients also had secondary Sjogren's syndrome (sSS) Results: IgM and IgA RFs prevalence was similar in pSS and RA, whichever the antigene (Human or Rabbit IgG) used. However, RA patients with sSS showed a tendency to present more often RF positivity, longer disease duration and higher ESR and CRP when compared with pSS patients with arthritis. Anti-CCP-Abs were detected in 64,5% of RA patients and in only 6,9% of pSS patients (p<0,0005). Anti-CCP-Abs were more often positive in RA patients with sSS (RA/sSS) (8 patients, 80%) than in RA patients without sSS (18 patients, 58,1%), and were absent in pSS patients with arthritis. RF-positive pSS patients presented more often pulmonary involvement and higher inflammatory parameters, and less often neuropathy compared to RF-negative patients. In controls, anti-CCP-Abs were absent and REs were negligible. Conclusions: Anti-CCP-Abs were detected in only a few pSS patients, none of whom presented arthritis, which contrasts with the high frequency of these antibodies in RA/sSS. These results suggest that anti-CCP-Abs could be useful in the distinction between pSS and RA with sSS. Although not useful for the differential diagnosis between RA and pSS, RFs may have a prognostic role in pSS.

KW - IGM

KW - RheumatoidArthritisCLINICAL-SIGNIFICANCE

KW - ELISA ASSAYS

KW - Anti-CCP Antibodies

KW - Rheumatoid Factors

KW - PREVALENCE

KW - Sjogren's Syndrome

KW - DISEASE

KW - ARTHRITIS

KW - AUTOANTIBODIES

KW - Sjögren’s Syndrome

KW - Anti-CCP Antibodies

KW - Rheumatoid Factors

KW - Rheumatoid Arthritis

M3 - Article

VL - 34

SP - 608

EP - 612

JO - Acta reumatologica portuguesa

JF - Acta reumatologica portuguesa

SN - 0303-464X

IS - 4

ER -