Anti-cancer precision theranostics: a focus on multifunctional gold nanoparticles

Rita M. Cabral, Pedro Baptista

Research output: Contribution to journalLiterature review

40 Citations (Scopus)

Abstract

Gold nanoparticles have been appointed as cutting-edge platforms for combined diagnostic and therapeutic approaches due to their exquisite physicochemical and optical properties. In particular, their potential benefits in cancer settings are enormous, as they can serve as targeted vehicles for controlled drug release, photothermal therapy and gene therapy, as well as contrast imaging agents to allow for real-time monitoring of both disease and therapeutic progression. These theranostic platforms represent powerful image-guided therapeutics, tailored to maximize individual patient benefit and with the ability to significantly minimize toxic side effects. Here the authors review some of the recent advances on the development of gold nanoparticle conjugates for combined diagnostics and therapy, while reflecting on the obstacles toward translational research.

Original languageEnglish
Pages (from-to)1041-1052
Number of pages12
JournalExpert Review Of Molecular Diagnostics
Volume14
Issue number8
DOIs
Publication statusPublished - 1 Nov 2014

Keywords

  • cancer
  • cancer therapy
  • gold nanoparticle
  • molecular diagnostics
  • nanotheranostics
  • NEAR-INFRARED LIGHT
  • ENHANCED RAMAN-SCATTERING
  • DRUG-DELIVERY
  • COMPUTED-TOMOGRAPHY
  • CANCER-CELLS
  • MULTIDRUG-RESISTANCE
  • PHOTOTHERMAL THERAPY
  • HIGH-RESOLUTION
  • LOADED CELLS
  • NANORODS

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