Abstract
In this study we report negative ion fragmentation patterns obtained from time-of-flight (TOF) mass spectrometry in potassium-uridine collisions at 30, 70 and 100 eV. The dominant fragments from uridine are also the most abundant from the individual units in potassium collisions with uracil, tetrahydrofuran (THF) and D-ribose. We observe no dehydrogenated parent anion formation. Special emphasis is given to the dissociation mechanisms lending support to the breaking of the N-glycosidic bond as an initial step in the fragmentation of the transient negative ion (TNI). Within their role as sugar unit surrogates, THF and D-ribose (DR) provide useful information for the study of uridine, and presumably other nucleosides from the point of view of DNA/RNA subunits integrity in the biological environment. (C) 2014 Elsevier B.V. All rights reserved.
Original language | English |
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Pages (from-to) | 243-247 |
Number of pages | 5 |
Journal | International Journal of Mass Spectrometry |
Volume | 365-366 |
DOIs | |
Publication status | Published - 15 May 2014 |
Keywords
- Atomic collisions
- Electron transfer
- Negative ion
- Nucleoside
- Uridine