Anion formation in gas-phase potassium-uridine collisions

Diogo Almeida, F. Ferreira da Silva, Janina Kopyra, Gustavo Garcia, Paulo Limão-Vieira

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In this study we report negative ion fragmentation patterns obtained from time-of-flight (TOF) mass spectrometry in potassium-uridine collisions at 30, 70 and 100 eV. The dominant fragments from uridine are also the most abundant from the individual units in potassium collisions with uracil, tetrahydrofuran (THF) and D-ribose. We observe no dehydrogenated parent anion formation. Special emphasis is given to the dissociation mechanisms lending support to the breaking of the N-glycosidic bond as an initial step in the fragmentation of the transient negative ion (TNI). Within their role as sugar unit surrogates, THF and D-ribose (DR) provide useful information for the study of uridine, and presumably other nucleosides from the point of view of DNA/RNA subunits integrity in the biological environment. (C) 2014 Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)243-247
Number of pages5
JournalInternational Journal of Mass Spectrometry
Volume365-366
DOIs
Publication statusPublished - 15 May 2014

Keywords

  • Atomic collisions
  • Electron transfer
  • Negative ion
  • Nucleoside
  • Uridine

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