Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 243-247 |
| Number of pages | 5 |
| Journal | International Journal of Mass Spectrometry |
| Volume | 365-366 |
| DOIs | |
| Publication status | Published - 15 May 2014 |
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Keywords
- Atomic collisions
- Electron transfer
- Negative ion
- Nucleoside
- Uridine
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Anion formation in gas-phase potassium-uridine collisions. / Almeida, Diogo; da Silva, F. Ferreira; Kopyra, Janina; Garcia, Gustavo; Limão-Vieira, Paulo.
In: International Journal of Mass Spectrometry, Vol. 365-366, 15.05.2014, p. 243-247.Research output: Contribution to journal › Article
TY - JOUR
T1 - Anion formation in gas-phase potassium-uridine collisions
AU - Almeida, Diogo
AU - da Silva, F. Ferreira
AU - Kopyra, Janina
AU - Garcia, Gustavo
AU - Limão-Vieira, Paulo
N1 - D.A. and F.F.S. acknowledge the Portuguese Foundation for Science and Technology (FCT-MEC) for post-doctoral SFRH/BPD/68979/2010 and SFRH/BPD/99261/2013 grants, respectively. P.L.V. acknowledges his visiting Professor position at The Open University, UK. We also acknowledge partial funding from PEst-OE/FIS/UI0068/2011 and PTDC/FIS-ATO/1832/2012 grants through FCT-MEC, and from the Spanish Ministerio de Economia y Competitividad (Project No. FIS 2012-31230). Some of this work forms part of the EU/ESF COST Action Nano-IBCT-MP1002. J.K. acknowledges support from EU/ESF COST Action MP1002 (Nano-IBCT) for a short term scientific visit to Lisbon.
PY - 2014/5/15
Y1 - 2014/5/15
N2 - In this study we report negative ion fragmentation patterns obtained from time-of-flight (TOF) mass spectrometry in potassium-uridine collisions at 30, 70 and 100 eV. The dominant fragments from uridine are also the most abundant from the individual units in potassium collisions with uracil, tetrahydrofuran (THF) and D-ribose. We observe no dehydrogenated parent anion formation. Special emphasis is given to the dissociation mechanisms lending support to the breaking of the N-glycosidic bond as an initial step in the fragmentation of the transient negative ion (TNI). Within their role as sugar unit surrogates, THF and D-ribose (DR) provide useful information for the study of uridine, and presumably other nucleosides from the point of view of DNA/RNA subunits integrity in the biological environment. (C) 2014 Elsevier B.V. All rights reserved.
AB - In this study we report negative ion fragmentation patterns obtained from time-of-flight (TOF) mass spectrometry in potassium-uridine collisions at 30, 70 and 100 eV. The dominant fragments from uridine are also the most abundant from the individual units in potassium collisions with uracil, tetrahydrofuran (THF) and D-ribose. We observe no dehydrogenated parent anion formation. Special emphasis is given to the dissociation mechanisms lending support to the breaking of the N-glycosidic bond as an initial step in the fragmentation of the transient negative ion (TNI). Within their role as sugar unit surrogates, THF and D-ribose (DR) provide useful information for the study of uridine, and presumably other nucleosides from the point of view of DNA/RNA subunits integrity in the biological environment. (C) 2014 Elsevier B.V. All rights reserved.
KW - Atomic collisions
KW - Electron transfer
KW - Negative ion
KW - Nucleoside
KW - Uridine
U2 - 10.1016/j.ijms.2014.01.023
DO - 10.1016/j.ijms.2014.01.023
M3 - Article
VL - 365-366
SP - 243
EP - 247
JO - International Journal of Mass Spectrometry
JF - International Journal of Mass Spectrometry
SN - 1387-3806
ER -