Analysis of TPI gene promoter variation in three sub-Saharan Africa population samples

Licínio Manco, Patrícia Machado, Dinora Lopes, Fátima Nogueira, Virgílio E do Rosário, Pedro L. Alonso, Luís Varandas, Maria de Jesus Trovoada, António Amorim, Ana Paula Arez

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Population samples from Angola, Mozambique, and S. Tomé e Príncipe were screened for the TPI gene promoter variants -5A→G, -8G→A and -24T→G. Three haplotypes were identified in the three populations: the haplotype -5A-8G-24T (average frequency 65.3%) and two less common haplotypes -5G-8G-24T (average frequency 24.7%) and -5G-8A-24T (average frequency 10.0%). A population sample from Central Portugal showed the haplotype -5A-8G-24T in 139 chromosomes and one subject heterozygous for haplotype -5G-8A-24G. The exact test of sample differentiation among three groups of malaria-infected individuals classified according to the severity of the disease showed no significant differences. We confirmed TPI gene diversity in sub-Saharan Africa, but we could not detect any association between TPI promoter variation and a malarial protective effect. Larger scale epidemiological studies are thus required to clarify this putative mechanism of natural host defense against this worldwide public health problem.

Original languageEnglish
Pages (from-to)118-120
Number of pages3
JournalAmerican Journal of Human Biology
Issue number1
Publication statusPublished - Jan 2009


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