TY - JOUR
T1 - Analysis of TPI gene promoter variation in three sub-Saharan Africa population samples
AU - Manco, Licínio
AU - Machado, Patrícia
AU - Lopes, Dinora
AU - Nogueira, Fátima
AU - do Rosário, Virgílio E
AU - Alonso, Pedro L.
AU - Varandas, Luís
AU - Trovoada, Maria de Jesus
AU - Amorim, António
AU - Arez, Ana Paula
PY - 2009/1
Y1 - 2009/1
N2 - Population samples from Angola, Mozambique, and S. Tomé e Príncipe were screened for the TPI gene promoter variants -5A→G, -8G→A and -24T→G. Three haplotypes were identified in the three populations: the haplotype -5A-8G-24T (average frequency 65.3%) and two less common haplotypes -5G-8G-24T (average frequency 24.7%) and -5G-8A-24T (average frequency 10.0%). A population sample from Central Portugal showed the haplotype -5A-8G-24T in 139 chromosomes and one subject heterozygous for haplotype -5G-8A-24G. The exact test of sample differentiation among three groups of malaria-infected individuals classified according to the severity of the disease showed no significant differences. We confirmed TPI gene diversity in sub-Saharan Africa, but we could not detect any association between TPI promoter variation and a malarial protective effect. Larger scale epidemiological studies are thus required to clarify this putative mechanism of natural host defense against this worldwide public health problem.
AB - Population samples from Angola, Mozambique, and S. Tomé e Príncipe were screened for the TPI gene promoter variants -5A→G, -8G→A and -24T→G. Three haplotypes were identified in the three populations: the haplotype -5A-8G-24T (average frequency 65.3%) and two less common haplotypes -5G-8G-24T (average frequency 24.7%) and -5G-8A-24T (average frequency 10.0%). A population sample from Central Portugal showed the haplotype -5A-8G-24T in 139 chromosomes and one subject heterozygous for haplotype -5G-8A-24G. The exact test of sample differentiation among three groups of malaria-infected individuals classified according to the severity of the disease showed no significant differences. We confirmed TPI gene diversity in sub-Saharan Africa, but we could not detect any association between TPI promoter variation and a malarial protective effect. Larger scale epidemiological studies are thus required to clarify this putative mechanism of natural host defense against this worldwide public health problem.
UR - http://www.scopus.com/inward/record.url?scp=59549103434&partnerID=8YFLogxK
UR - https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajhb.20819
U2 - 10.1002/ajhb.20819
DO - 10.1002/ajhb.20819
M3 - Article
C2 - 18792062
AN - SCOPUS:59549103434
SN - 1042-0533
VL - 21
SP - 118
EP - 120
JO - American Journal of Human Biology
JF - American Journal of Human Biology
IS - 1
ER -