TY - JOUR
T1 - Analysis of Food by High Performance Liquid Chromatography Coupled with Coulometric Detection and Related Techniques: A Review
AU - Sontag, Gerhard
AU - Pinto, Maria I.
AU - Noronha, João P.
AU - Burrows, Hugh D.
N1 - H.D.B. thanks the Centro de Quimica de Coimbra (CQC) for funding by the Fundacao para a Ciencia e Tecnologica (FCT) through the programmes UID/QUI/UI0313/2019 and POCI-01-0145-FEDER-007630.
PY - 2019/4/17
Y1 - 2019/4/17
N2 - The development of single coulometric cells in combination with high performance liquid chromatography to dual cells and to the coulometric electrode array detector is described. An overview is given about the application of these methods in food chemistry. Easily oxidizable compounds, such as phenolic substances, pesticides, or vitamins, can be determined, as well as substances with high oxidation potentials or electroinactive compounds. Substances exhibiting poor electrochemical activity can be transformed to electroactive compounds by precolumn derivatization, postcolumn photochemical reactions, postcolumn enzyme reactors, or by using the oxidative/reductive mode for coulometric electrode array detection. Furthermore, it is shown that the interesting combination of high performance liquid chromatography with electrochemistry and mass spectrometry has opened further possibilities with respect to interpretation of redox reactions, drug metabolism studies, metabolomics, and electrochemical derivatization.
AB - The development of single coulometric cells in combination with high performance liquid chromatography to dual cells and to the coulometric electrode array detector is described. An overview is given about the application of these methods in food chemistry. Easily oxidizable compounds, such as phenolic substances, pesticides, or vitamins, can be determined, as well as substances with high oxidation potentials or electroinactive compounds. Substances exhibiting poor electrochemical activity can be transformed to electroactive compounds by precolumn derivatization, postcolumn photochemical reactions, postcolumn enzyme reactors, or by using the oxidative/reductive mode for coulometric electrode array detection. Furthermore, it is shown that the interesting combination of high performance liquid chromatography with electrochemistry and mass spectrometry has opened further possibilities with respect to interpretation of redox reactions, drug metabolism studies, metabolomics, and electrochemical derivatization.
KW - food analysis
KW - HPLC/coulometric detection
KW - HPLC/electrochemistry/mass spectrometry
UR - http://www.scopus.com/inward/record.url?scp=85064542161&partnerID=8YFLogxK
U2 - 10.1021/acs.jafc.9b00003
DO - 10.1021/acs.jafc.9b00003
M3 - Review article
C2 - 30900882
AN - SCOPUS:85064542161
SN - 0021-8561
VL - 67
SP - 4113
EP - 4144
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
IS - 15
ER -