Analysis of Food by High Performance Liquid Chromatography Coupled with Coulometric Detection and Related Techniques: A Review

Gerhard Sontag, Maria I. Pinto, João P. Noronha, Hugh D. Burrows

Research output: Contribution to journalReview articlepeer-review

29 Citations (Scopus)

Abstract

The development of single coulometric cells in combination with high performance liquid chromatography to dual cells and to the coulometric electrode array detector is described. An overview is given about the application of these methods in food chemistry. Easily oxidizable compounds, such as phenolic substances, pesticides, or vitamins, can be determined, as well as substances with high oxidation potentials or electroinactive compounds. Substances exhibiting poor electrochemical activity can be transformed to electroactive compounds by precolumn derivatization, postcolumn photochemical reactions, postcolumn enzyme reactors, or by using the oxidative/reductive mode for coulometric electrode array detection. Furthermore, it is shown that the interesting combination of high performance liquid chromatography with electrochemistry and mass spectrometry has opened further possibilities with respect to interpretation of redox reactions, drug metabolism studies, metabolomics, and electrochemical derivatization.

Original languageEnglish
Pages (from-to)4113-4144
Number of pages32
JournalJournal of Agricultural and Food Chemistry
Volume67
Issue number15
DOIs
Publication statusPublished - 17 Apr 2019

Keywords

  • food analysis
  • HPLC/coulometric detection
  • HPLC/electrochemistry/mass spectrometry

Fingerprint

Dive into the research topics of 'Analysis of Food by High Performance Liquid Chromatography Coupled with Coulometric Detection and Related Techniques: A Review'. Together they form a unique fingerprint.

Cite this