An Update on the Implications of New Psychoactive Substances in Public Health

Ana Y. Simão, Mónica Antunes, Emanuel Cabral, Patrik Oliveira, Luana M. Rosendo, Ana Teresa Brinca, Estefânia Alves, Hernâni Marques, Tiago Rosado, Luís A. Passarinha, Maristela Andraus, Mário Barroso, Eugenia Gallardo

Research output: Contribution to journalReview articlepeer-review

19 Citations (Scopus)
230 Downloads (Pure)


The emergence of new psychoactive substances has earned a great deal of attention, and several reports of acute poisoning and deaths have been issued involving, for instance, synthetic opiates. In recent years, there have been profound alterations in the legislation concerning consump-tion, marketing, and synthesis of these compounds; rapid alert systems have also been subject to changes, and new substances and new markets, mainly through the internet, have appeared. Their effects and how they originate in consumers are still mostly unknown, primarily in what concerns chronic toxicity. This review intends to provide a detailed description of these substances from the point of view of consumption, toxicokinetics, and health consequences, including case reports on intoxications in order to help researchers and public health agents working daily in this area.

Original languageEnglish
Article number4869
Number of pages42
JournalInternational Journal of Environmental Research and Public Health
Issue number8
Publication statusPublished - 17 Apr 2022


  • health problems
  • new psychoactive substances
  • toxicity


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