An international case-vignette study to assess general practitioner“ willingness to deprescribe (LESS)

Katharina Tabea Jungo, Sophie Mantelli, Zsofia Rozsnyai, A. Missiou, B. G. Kitanovska, B. Weltermann, Canan Tuz, Christian D. Mallen, C. Collins, D. Kurpas, F. G. Franco, Ferdinando Petrazzuoli, H. Thulesius, H. Lingner, K. L. Johansen, K. Wallis, K. Hoffmann, L. Peremans, L. Pilv, M. ŠterMartin Sattler, Milly A. van der Ploeg, P. Torzsa, P. Kánská, Shlomo Vinker, R. Assenova, R. Bravo, Rita P. A. Viegas, Rosy Tsopra, Sanda Kreitmayer Peštić, Sandra Gintere, T. Koskela, Vanja Lazić, Victoria Tkachenko, E. Reeve, C. Luymes, R. Poortvliet, A. Chiolero, N. Rodondi, Jacobijn Gussekloo, Sven Streit

Research output: Contribution to conferencePaperpeer-review


Globally, many oldest-old (>80 years of age) suffer from several chronic conditions and take multiple medications. Ideally, their general practitioners (GPs) regularly and systematically search for inappropriate medications and, if necessary, deprescribe those. However, deprescribing is challenging due to numerous barriers not only within patients, but also within GPs. Research questions: How does the willingness to deprescribe in oldest-old with polypharmacy differ in GPs from different countries? What factors do GPs in different contexts perceive as important for deprescribing? Method: We assess GPs' willingness to deprescribe and the factors GPs perceive to influence their deprescribing decisions in a cross-sectional survey using case-vignettes of oldest-old patients with polypharmacy. We approach GPs in 28 European countries as well as in Israel, Brazil and New Zealand through national coordinators, who administer the survey in their GP network. The case vignettes differ in how dependent patients are and whether or not they have a history of cardiovascular disease (CVD). For each case vignette, GPs are asked if and which medication they would deprescribe. GPs further rate to what extent pre-defined factors influence their deprescribe decisions. We will compare the willingness to deprescribe and the factors influencing deprescribing across countries. Multilevel models will be used to analyze the proportions of the deprescribed medications per case along the continuum of dependency and history of CVD and to analyze the factors perceived as influencing deprescribing decisions. Results: As of early-July 2018, the survey has been distributed in 14 countries and >650 responses have been returned. We will present first results at the conference. Conclusions: First, assessing GPs’ willingness to deprescribe and comparing the factors influencing GPs’ deprescribing decisions across countries will allow an understanding of the expected variation in the willingness to deprescribe across different contexts. Second, it will enable the tailoring of specific interventions that might facilitate deprescribing in oldest-old patients. Points for discussion: How can we explain differences across countries? How can the results be translated into practice in order to help GPs to optimize deprescribing practices? What factors could help GPs to implement deprescribing in oldest-old patients with polypharmacy?
Original languageEnglish
Publication statusPublished - 2018
Event87th Meeting of the European General Practice Research Network: Abstract Book of the 87th EGPRN Meeting - Sarajevo , Sarajevo, Bosnia and Herzegovina
Duration: 4 Oct 20187 Oct 2018


Conference87th Meeting of the European General Practice Research Network
Country/TerritoryBosnia and Herzegovina


Dive into the research topics of 'An international case-vignette study to assess general practitioner“ willingness to deprescribe (LESS)'. Together they form a unique fingerprint.

Cite this