An in vitro and in silico evaluation of bioactive potential of cornelian cherry (Cornus mas L.) extracts rich in polyphenols and iridoids

Bojana Blagojević, Dejan Agić, Ana Teresa Serra, Sara Matić, Mihaela Matovina, Sandra Bijelić, Boris M. Popović

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

In the present research, seven different cornelian cherry (Cornus mas L.) cultivars and selections were examined. In vitro and in silico methods were applied for determining and correlating phytochemical constituents and biological potential. Loganic acid, cornuside, cyanidin 3-galactoside, and pelargonidin 3-galactoside were determined as the most dominant compounds, presenting ≥90% of the all detected iridoid and phenolic constituents in the extracts. Cornelian cherry fruits were characterized by high antioxidant capacity and antiproliferative activity on human colon cancer cells (HT29). It was observed the strong inhibitory potential of α-amylase, α-glucosidase, and dipeptidyl peptidase III (DPP III) enzyme activities. Principal component analysis (PCA) was used as a very helpful tool to discriminate the constituents with the highest contribution to tested bioactivities and to highlight the most potent genotypes. PCA, together with binding energies measurements and docking analysis, pointed out pelargonidin 3-robinobioside as the strongest inhibitor of α-glucosidase.

Original languageEnglish
Article number127619
JournalFood Chemistry
Volume335
DOIs
Publication statusPublished - 15 Jan 2021

Keywords

  • Antioxidants
  • Cornelian cherry
  • Cornus mas
  • Dipeptidyl peptidase III
  • HT29
  • α-Amylase
  • α-Glucosidase

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