An immunohistochemical analysis of Rab27B distribution in fetal and adult tissue

An Hendrix; Kathleen Lambein; Wendy Westbroek; Miguel C. Seabra; Veronique Cocquyt; Patrick Pauwels; Marc Bracke; Christian Gespach; Olivier De Wever

doi:10.1387/ijdb.120008ah

An immunohistochemical analysis of Rab27B distribution in fetal and adult tissue

An Hendrix, Kathleen Lambein, Wendy Westbroek, Miguel C. Seabra, Veronique Cocquyt, Patrick Pauwels, Marc Bracke, Christian Gespach, Olivier De Wever

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Abstract

Regulated secretory pathways coordinated by small Rab GTPases are critically involved in intercellular communications. Here, we report the expression and localization of Rab27B in developing and differentiated epithelial human tissues by immunohistochemistry. Rab27B is poorly expressed in fetal tissues suggesting that several developmental mechanisms involved in epithelial differentiation and functions are mediated by other secretory Rab GTPases, such as Rab27A or Rab3 family members. In adult tissues, Rab27B is expressed in a wide variety of differentiated secretory epithelial cells, including those lining the salivary gland, gastrointestinal, mammary and prostate tracts. The complex pattern of Rab27B expression indicates that dysregulation of Rab27B-mediated secretion may have profound implications for disease pathology.

Original language	English
Pages (from-to)	363-368
Number of pages	6
Journal	International Journal of Developmental Biology
Volume	56
Issue number	5
DOIs	https://doi.org/10.1387/ijdb.120008ah
Publication status	Published - 2012

Keywords

Development
Exocytosis
Rab27
Secretory Rab
Small GTPase

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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pages = "363--368",

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AU - Hendrix, An

AU - Lambein, Kathleen

AU - Westbroek, Wendy

AU - Seabra, Miguel C.

AU - Cocquyt, Veronique

AU - Pauwels, Patrick

AU - Bracke, Marc

AU - Gespach, Christian

AU - De Wever, Olivier

PY - 2012

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AB - Regulated secretory pathways coordinated by small Rab GTPases are critically involved in intercellular communications. Here, we report the expression and localization of Rab27B in developing and differentiated epithelial human tissues by immunohistochemistry. Rab27B is poorly expressed in fetal tissues suggesting that several developmental mechanisms involved in epithelial differentiation and functions are mediated by other secretory Rab GTPases, such as Rab27A or Rab3 family members. In adult tissues, Rab27B is expressed in a wide variety of differentiated secretory epithelial cells, including those lining the salivary gland, gastrointestinal, mammary and prostate tracts. The complex pattern of Rab27B expression indicates that dysregulation of Rab27B-mediated secretion may have profound implications for disease pathology.

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KW - Exocytosis

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An immunohistochemical analysis of Rab27B distribution in fetal and adult tissue

Abstract

Keywords

UN SDGs

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