An efficient synthesis of optically active [4-13 c] labelled quorum sensing signal autoinducer-2

Research output: Contribution to journalArticlepeer-review

Abstract

A new synthetic route for the quorum sensing signal Autoinducer-2 (AI-2) is described and used for the preparation of [4-13 C]-AI-2 starting from [1-13 C]-bromoacetic acid. The key step in this process was the enantioselective reduction of an intermediate ketone. This synthesis pro-vides, selectively, both enantiomers of the labelled or unlabelled parent compound, (R) or (S)-4,5-dihydroxypentane-2,3-dione (DPD) and was used for an improved synthesis of [1-13 C]-AI-2.

Original languageEnglish
Article number369
JournalMolecules
Volume26
Issue number2
DOIs
Publication statusPublished - 1 Jan 2021

Keywords

  • C-DPD
  • AI-2
  • DPD
  • Enantioselective synthesis
  • Quorum sensing

Fingerprint

Dive into the research topics of 'An efficient synthesis of optically active [4-13 c] labelled quorum sensing signal autoinducer-2'. Together they form a unique fingerprint.

Cite this