An efficient and expeditious Fmoc protection of amines and amino acids in aqueous media

Paula Cristina de Sério Branco

doi:10.1039/c1gc15868f

An efficient and expeditious Fmoc protection of amines and amino acids in aqueous media

Paula Cristina de Sério Branco

Research output: Contribution to journal › Article › peer-review

91 Citations (Scopus)

Abstract

A new and environmentally friendly Fmoc protection of a variety of aliphatic and aromatic amines, amino acids, amino alcohols and amino phenols is reported in aqueous media under mild and catalyst-free conditions. The reaction proved to be chemoselective in presence of ambident nucleophiles

Original language	Unknown
Pages (from-to)	3355-3359
Journal	Green Chemistry
Volume	13
Issue number	12
DOIs	https://doi.org/10.1039/c1gc15868f
Publication status	Published - 1 Jan 2011

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10.1039/c1gc15868f

Cite this

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title = "An efficient and expeditious Fmoc protection of amines and amino acids in aqueous media",

abstract = "A new and environmentally friendly Fmoc protection of a variety of aliphatic and aromatic amines, amino acids, amino alcohols and amino phenols is reported in aqueous media under mild and catalyst-free conditions. The reaction proved to be chemoselective in presence of ambident nucleophiles",

keywords = "HYDRATION, CONVENIENT, WATER, AMIDES, NITRILES, PHASE PEPTIDE-SYNTHESIS, CATALYST, BOC, OLVENT-FREE CONDITIONS, CHEMISTRY",

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AB - A new and environmentally friendly Fmoc protection of a variety of aliphatic and aromatic amines, amino acids, amino alcohols and amino phenols is reported in aqueous media under mild and catalyst-free conditions. The reaction proved to be chemoselective in presence of ambident nucleophiles

KW - HYDRATION

KW - CONVENIENT

KW - WATER

KW - AMIDES

KW - NITRILES

KW - PHASE PEPTIDE-SYNTHESIS

KW - CATALYST

KW - BOC

KW - OLVENT-FREE CONDITIONS

KW - CHEMISTRY

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DO - 10.1039/c1gc15868f

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JO - Green Chemistry

JF - Green Chemistry

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