An artificial CO-releasing metalloprotein built by histidine-selective metallation

Inês S. Albuquerque, Hélia F. Jeremias, Miguel Chaves-Ferreira, Dijana Matak-Vinkovic, Omar Boutureira, Gonçalo J L Bernardes, Carlos Jose Romao

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

We report the design and synthesis of an aquacarbonyl Ru(ii) dication cis-[Ru(CO)2(H2O)4]2+ reagent for histidine (His)-selective metallation of interleukin (IL)-8 at site 33. The artificial, non-toxic interleukin (IL)-8-RuII(CO)2 metalloprotein retained IL-8-dependent neutrophil chemotactic activity and was shown to spontaneously release CO in live cells. This journal is

Original languageEnglish
Pages (from-to)3993-3996
Number of pages4
JournalChemical Communications
Volume51
Issue number19
DOIs
Publication statusPublished - 7 Mar 2015

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