TY - JOUR
T1 - An artificial CO-releasing metalloprotein built by histidine-selective metallation
AU - Albuquerque, Inês S.
AU - Jeremias, Hélia F.
AU - Chaves-Ferreira, Miguel
AU - Matak-Vinkovic, Dijana
AU - Boutureira, Omar
AU - Bernardes, Gonçalo J L
AU - Romao, Carlos Jose
PY - 2015/3/7
Y1 - 2015/3/7
N2 - We report the design and synthesis of an aquacarbonyl Ru(ii) dication cis-[Ru(CO)2(H2O)4]2+ reagent for histidine (His)-selective metallation of interleukin (IL)-8 at site 33. The artificial, non-toxic interleukin (IL)-8-RuII(CO)2 metalloprotein retained IL-8-dependent neutrophil chemotactic activity and was shown to spontaneously release CO in live cells. This journal is
AB - We report the design and synthesis of an aquacarbonyl Ru(ii) dication cis-[Ru(CO)2(H2O)4]2+ reagent for histidine (His)-selective metallation of interleukin (IL)-8 at site 33. The artificial, non-toxic interleukin (IL)-8-RuII(CO)2 metalloprotein retained IL-8-dependent neutrophil chemotactic activity and was shown to spontaneously release CO in live cells. This journal is
UR - http://www.scopus.com/inward/record.url?scp=84923346124&partnerID=8YFLogxK
U2 - 10.1039/c4cc10204e
DO - 10.1039/c4cc10204e
M3 - Article
C2 - 25660271
AN - SCOPUS:84923346124
SN - 1359-7345
VL - 51
SP - 3993
EP - 3996
JO - Chemical Communications
JF - Chemical Communications
IS - 19
ER -