Osteoporosis (OP) is a systemic skeletal disease characterized by a total bone mass reduction, followed by the microarchitectural deterioration of bone structure. These factors lead to a state of enhanced bone fragility and hence susceptibility to fracture . OP diagnosis is still mainly based on T-score, computed from bone mineral density (BMD) measurements, obtained by Dual energy X-ray Absorptiometry (DXA). However, fracture incidence cannot be totally explained by this variable. On the other hand, the development of computational bone remodeling models provides valuable tools for the assessment of bone density as well as bone micro-architecture. In this sense, this work conjugates a hierarchical bone remodeling model with DXA as an approach towards patient-specific bone remodeling simulation in OP context. This analysis was preceded by the computational model validation .
|Title of host publication||----|
|Publication status||Published - 1 Jan 2009|
|Event||International Conference on Computational Biomechanics - |
Duration: 1 Jan 2009 → …
|Conference||International Conference on Computational Biomechanics|
|Period||1/01/09 → …|