TY - JOUR
T1 - Alpha-tomatine and the two sides of the same coin
T2 - An anti-nutritional glycoalkaloid with potential in human health
AU - Faria-Silva, Catarina
AU - de Sousa, Miriam
AU - Carvalheiro, Manuela Colla
AU - Simões, Pedro
AU - Simões, Sandra
N1 - info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04138%2F2020/PT#
info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FSAU-SER%2F30197%2F2017/PT#
Funding Information:
This work was supported by Fundação para a Ciência e a tecnologia (FCT) through the projects UID/DTP/04138/2020 of the Research Institute for Medicines - iMed.ULisboa and FEDER-LISBOA-010141- FEDER-030197.
Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2022/10/15
Y1 - 2022/10/15
N2 - Discovery of new selective anticancer, anti-inflammatory, and anti-microbial agents is a crucial and necessary step to ensure a pipeline for innovative products to improve disease management. Several new bioactive agents derived from plants have been investigated and an example is the steroidal glycoalkaloid (SGA) class of natural products found in plants, investigated for their health-beneficial biological activities. Among them, α-tomatine is a SGA derived from the plant parts of unripe green tomatoes. In this review we aimed at searching for two different perspectives to study α-tomatine from green tomatoes, namely from its dual action point of view: as an anti-nutrient and as a health promoter. The aspects associated to its synthesis and degradation were considered. Finally, the current strategies for its extraction from natural sources and the methodologies commonly used for its identification and quantification were discussed.
AB - Discovery of new selective anticancer, anti-inflammatory, and anti-microbial agents is a crucial and necessary step to ensure a pipeline for innovative products to improve disease management. Several new bioactive agents derived from plants have been investigated and an example is the steroidal glycoalkaloid (SGA) class of natural products found in plants, investigated for their health-beneficial biological activities. Among them, α-tomatine is a SGA derived from the plant parts of unripe green tomatoes. In this review we aimed at searching for two different perspectives to study α-tomatine from green tomatoes, namely from its dual action point of view: as an anti-nutrient and as a health promoter. The aspects associated to its synthesis and degradation were considered. Finally, the current strategies for its extraction from natural sources and the methodologies commonly used for its identification and quantification were discussed.
KW - Alpha-tomatine
KW - Anticancer activity
KW - Green tomatoes
KW - Steroidal glycoalkaloids
UR - http://www.scopus.com/inward/record.url?scp=85131702407&partnerID=8YFLogxK
U2 - 10.1016/j.foodchem.2022.133261
DO - 10.1016/j.foodchem.2022.133261
M3 - Review article
C2 - 35640336
AN - SCOPUS:85131702407
SN - 0308-8146
VL - 391
JO - Food Chemistry
JF - Food Chemistry
M1 - 133261
ER -
