All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery

Clarinda Costa; Zehua Liu; João P. Martins; Alexandra Correia; Patrícia Figueiredo; Antti Rahikkala; Wei Li; Jani Seitsonen; Janne Ruokolainen; Sami Pekka Hirvonen; Ana Aguiar-Ricardo; M. Luísa Corvo; Hélder A. Santos

doi:10.1039/d0bm00743a

All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery

Clarinda Costa, Zehua Liu, João P. Martins, Alexandra Correia, Patrícia Figueiredo, Antti Rahikkala, Wei Li, Jani Seitsonen, Janne Ruokolainen, Sami Pekka Hirvonen, Ana Aguiar-Ricardo, M. Luísa Corvo, Hélder A. Santos

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Abstract

Here, a continuous two-step glass-capillary microfluidic technique to produce a multistage oral delivery system is reported. Insulin is successfully encapsulated into liposomes, which are coated with chitosan to improve their mucoadhesion. The encapsulation in an enteric polymer offers protection from the harsh gastric conditions. Insulin permeability is enhanced across an intestinal monolayer.

Original language	English
Pages (from-to)	3270-3277
Number of pages	8
Journal	Biomaterials Science
Volume	8
Issue number	12
DOIs	https://doi.org/10.1039/d0bm00743a
Publication status	Published - 21 Jun 2020

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d0bm00743aFinal published version, 2.08 MBLicence: CC BY-NC

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Costa, C., Liu, Z., Martins, J. P., Correia, A., Figueiredo, P., Rahikkala, A., Li, W., Seitsonen, J., Ruokolainen, J., Hirvonen, S. P., Aguiar-Ricardo, A., Corvo, M. L., & Santos, H. A. (2020). All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery. Biomaterials Science, 8(12), 3270-3277. https://doi.org/10.1039/d0bm00743a

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title = "All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery",

abstract = "Here, a continuous two-step glass-capillary microfluidic technique to produce a multistage oral delivery system is reported. Insulin is successfully encapsulated into liposomes, which are coated with chitosan to improve their mucoadhesion. The encapsulation in an enteric polymer offers protection from the harsh gastric conditions. Insulin permeability is enhanced across an intestinal monolayer.",

author = "Clarinda Costa and Zehua Liu and Martins, {Jo{\~a}o P.} and Alexandra Correia and Patr{\'i}cia Figueiredo and Antti Rahikkala and Wei Li and Jani Seitsonen and Janne Ruokolainen and Hirvonen, {Sami Pekka} and Ana Aguiar-Ricardo and Corvo, {M. Lu{\'i}sa} and Santos, {H{\'e}lder A.}",

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year = "2020",

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doi = "10.1039/d0bm00743a",

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Costa, C, Liu, Z, Martins, JP, Correia, A, Figueiredo, P, Rahikkala, A, Li, W, Seitsonen, J, Ruokolainen, J, Hirvonen, SP, Aguiar-Ricardo, A, Corvo, ML & Santos, HA 2020, 'All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery', Biomaterials Science, vol. 8, no. 12, pp. 3270-3277. https://doi.org/10.1039/d0bm00743a

TY - JOUR

T1 - All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery

AU - Costa, Clarinda

AU - Liu, Zehua

AU - Martins, João P.

AU - Correia, Alexandra

AU - Figueiredo, Patrícia

AU - Rahikkala, Antti

AU - Li, Wei

AU - Seitsonen, Jani

AU - Ruokolainen, Janne

AU - Hirvonen, Sami Pekka

AU - Aguiar-Ricardo, Ana

AU - Corvo, M. Luísa

AU - Santos, Hélder A.

N1 - UIDB/50006/2020 PD/BD/142880/2018 UID/DTP/04138/2020

PY - 2020/6/21

Y1 - 2020/6/21

N2 - Here, a continuous two-step glass-capillary microfluidic technique to produce a multistage oral delivery system is reported. Insulin is successfully encapsulated into liposomes, which are coated with chitosan to improve their mucoadhesion. The encapsulation in an enteric polymer offers protection from the harsh gastric conditions. Insulin permeability is enhanced across an intestinal monolayer.

AB - Here, a continuous two-step glass-capillary microfluidic technique to produce a multistage oral delivery system is reported. Insulin is successfully encapsulated into liposomes, which are coated with chitosan to improve their mucoadhesion. The encapsulation in an enteric polymer offers protection from the harsh gastric conditions. Insulin permeability is enhanced across an intestinal monolayer.

UR - http://www.scopus.com/inward/record.url?scp=85086681572&partnerID=8YFLogxK

U2 - 10.1039/d0bm00743a

DO - 10.1039/d0bm00743a

M3 - Article

C2 - 32490443

AN - SCOPUS:85086681572

SN - 2047-4830

VL - 8

SP - 3270

EP - 3277

JO - Biomaterials Science

JF - Biomaterials Science

IS - 12

ER -

All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery

Abstract

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