Abstract

In this study, we aimed to evaluate the relationship between individual total exposure to air pollution and airway changes in a group of 51 wheezing children. Respiratory status was assessed four times (January 2006, June 2006, January 2007 and June 2007) during a 1-week period through a standardised questionnaire, spirometry, exhaled nitric oxide fraction and pH in exhaled breath condensate (EBC). Concentrations of particles with a 50% cut-off aerodynamic diameter of 10 mu m (PM10), O-3, NO2 and volatile organic compounds were estimated through direct measurements with an ad hoc device or air pollution modelling in the children's schools and at their homes in the same 4 weeks of the study. For each child, total exposure to the different air pollutants was estimated as a function of pollutant concentrations and daily activity patterns. Increasing total exposure to PM10, NO2, benzene, toluene and ethylbenzene was significantly associated with a decrease of forced expiratory volume in 1 s (FEV1) and with an increase of change in FEV1. Increasing exposure to NO2 and benzene was also related to a significant decrease of FEV1/forced vital capacity. Increasing exposure to PM10, NO2, benzene and ethylbenzene was associated with acidity of EBC. This study suggests an association in wheezing children between airway changes and total exposure to air pollutants, as estimated by taking into account the concentration in the various microenvironments attended by the children.
Original languageEnglish
Pages (from-to)246-253
JournalEuropean Respiratory Journal
Volume39
Issue number2
Publication statusPublished - 1 Jan 2012

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Respiratory Sounds
Air Pollution
Forced Expiratory Volume
Benzene
Air Pollutants
Volatile Organic Compounds
Spirometry
Vital Capacity
Toluene
Nitric Oxide
Equipment and Supplies
ethylbenzene

Cite this

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title = "Airways changes related to air pollution exposure in wheezing children",
abstract = "In this study, we aimed to evaluate the relationship between individual total exposure to air pollution and airway changes in a group of 51 wheezing children. Respiratory status was assessed four times (January 2006, June 2006, January 2007 and June 2007) during a 1-week period through a standardised questionnaire, spirometry, exhaled nitric oxide fraction and pH in exhaled breath condensate (EBC). Concentrations of particles with a 50{\%} cut-off aerodynamic diameter of 10 mu m (PM10), O-3, NO2 and volatile organic compounds were estimated through direct measurements with an ad hoc device or air pollution modelling in the children's schools and at their homes in the same 4 weeks of the study. For each child, total exposure to the different air pollutants was estimated as a function of pollutant concentrations and daily activity patterns. Increasing total exposure to PM10, NO2, benzene, toluene and ethylbenzene was significantly associated with a decrease of forced expiratory volume in 1 s (FEV1) and with an increase of change in FEV1. Increasing exposure to NO2 and benzene was also related to a significant decrease of FEV1/forced vital capacity. Increasing exposure to PM10, NO2, benzene and ethylbenzene was associated with acidity of EBC. This study suggests an association in wheezing children between airway changes and total exposure to air pollutants, as estimated by taking into account the concentration in the various microenvironments attended by the children.",
keywords = "BRONCHITIC SYMPTOMS, total exposure, volatile organic compounds, LONG-TERM EXPOSURE, RESPIRATORY HEALTH, LUNG-FUNCTION, CHILDHOOD ASTHMA, PARTICULATE MATTER, ASTHMATIC-CHILDREN, Breath condensate analysis, SCHOOL-CHILDREN, spirometry, EXHALED NITRIC-OXIDE, particles with a 50{\%} cut-off aerodynamic diameter of 10 mu m, VOLATILE ORGANIC-COMPOUNDS, NO2",
author = "Pinto, {Jos{\'e} Eduardo Ferreira Rosado} and Correia, {Iolanda Baptista Gon{\cc}alves Caires} and Martins, {Pedro Miguel Carvalho Diogo Carreiro} and Neuparth, {Nuno Manuel Barreiros} and Silva, {Ana Luisa Trigoso Papoila da}",
year = "2012",
month = "1",
day = "1",
language = "English",
volume = "39",
pages = "246--253",
journal = "European Respiratory Journal",
issn = "0903-1936",
publisher = "European Respiratory Society",
number = "2",

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TY - JOUR

T1 - Airways changes related to air pollution exposure in wheezing children

AU - Pinto, José Eduardo Ferreira Rosado

AU - Correia, Iolanda Baptista Gonçalves Caires

AU - Martins, Pedro Miguel Carvalho Diogo Carreiro

AU - Neuparth, Nuno Manuel Barreiros

AU - Silva, Ana Luisa Trigoso Papoila da

PY - 2012/1/1

Y1 - 2012/1/1

N2 - In this study, we aimed to evaluate the relationship between individual total exposure to air pollution and airway changes in a group of 51 wheezing children. Respiratory status was assessed four times (January 2006, June 2006, January 2007 and June 2007) during a 1-week period through a standardised questionnaire, spirometry, exhaled nitric oxide fraction and pH in exhaled breath condensate (EBC). Concentrations of particles with a 50% cut-off aerodynamic diameter of 10 mu m (PM10), O-3, NO2 and volatile organic compounds were estimated through direct measurements with an ad hoc device or air pollution modelling in the children's schools and at their homes in the same 4 weeks of the study. For each child, total exposure to the different air pollutants was estimated as a function of pollutant concentrations and daily activity patterns. Increasing total exposure to PM10, NO2, benzene, toluene and ethylbenzene was significantly associated with a decrease of forced expiratory volume in 1 s (FEV1) and with an increase of change in FEV1. Increasing exposure to NO2 and benzene was also related to a significant decrease of FEV1/forced vital capacity. Increasing exposure to PM10, NO2, benzene and ethylbenzene was associated with acidity of EBC. This study suggests an association in wheezing children between airway changes and total exposure to air pollutants, as estimated by taking into account the concentration in the various microenvironments attended by the children.

AB - In this study, we aimed to evaluate the relationship between individual total exposure to air pollution and airway changes in a group of 51 wheezing children. Respiratory status was assessed four times (January 2006, June 2006, January 2007 and June 2007) during a 1-week period through a standardised questionnaire, spirometry, exhaled nitric oxide fraction and pH in exhaled breath condensate (EBC). Concentrations of particles with a 50% cut-off aerodynamic diameter of 10 mu m (PM10), O-3, NO2 and volatile organic compounds were estimated through direct measurements with an ad hoc device or air pollution modelling in the children's schools and at their homes in the same 4 weeks of the study. For each child, total exposure to the different air pollutants was estimated as a function of pollutant concentrations and daily activity patterns. Increasing total exposure to PM10, NO2, benzene, toluene and ethylbenzene was significantly associated with a decrease of forced expiratory volume in 1 s (FEV1) and with an increase of change in FEV1. Increasing exposure to NO2 and benzene was also related to a significant decrease of FEV1/forced vital capacity. Increasing exposure to PM10, NO2, benzene and ethylbenzene was associated with acidity of EBC. This study suggests an association in wheezing children between airway changes and total exposure to air pollutants, as estimated by taking into account the concentration in the various microenvironments attended by the children.

KW - BRONCHITIC SYMPTOMS

KW - total exposure

KW - volatile organic compounds

KW - LONG-TERM EXPOSURE

KW - RESPIRATORY HEALTH

KW - LUNG-FUNCTION

KW - CHILDHOOD ASTHMA

KW - PARTICULATE MATTER

KW - ASTHMATIC-CHILDREN

KW - Breath condensate analysis

KW - SCHOOL-CHILDREN

KW - spirometry

KW - EXHALED NITRIC-OXIDE

KW - particles with a 50% cut-off aerodynamic diameter of 10 mu m

KW - VOLATILE ORGANIC-COMPOUNDS

KW - NO2

M3 - Article

VL - 39

SP - 246

EP - 253

JO - European Respiratory Journal

JF - European Respiratory Journal

SN - 0903-1936

IS - 2

ER -