Afterpotential characteristics and firing patterns in maturing rat hippocampal CA1 neurones in in vitro slices

Pedro Freire Costa; Maria Alexandra Ribeiro; Ana Isabel Santos

doi:10.1016/0165-3806(91)90174-H

Afterpotential characteristics and firing patterns in maturing rat hippocampal CA1 neurones in in vitro slices

Pedro Freire Costa, Maria Alexandra Ribeiro, Ana Isabel Santos

NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

The postnatal evolution of depolarizing after-potentials (DAPs) and after-hyperpolarizations (AHPs) was studied in rat CA1 hippocampal neurones (5-68 days of age) using in vitro slices. Results were pooled into 4 age groups: P_5-9, P_10-16, P_17-24 and P_26-68. In P_5-9 cells. DAPs were seen as passive signals, with a time constant similar to the time constant of the membrane. The evolution of the DAP was characterized by a decrease in amplitude, an increase in duration and a change in contour. In P_10-16 and P_17-24 cells, the DAPs often had a plateau or a hump-like shape which increased the probability of firing and the occurrence of spike doublets. The firing pattern and bursting behaviour of P_10-16 CA1 neurones differed from the pattern typical of the adult. P_5-9 and P_10-16 cells had post-burst AHPs with a smaller amplitude and a more prolonged early phase than at late stages of development.

Original language	English
Pages (from-to)	263-272
Number of pages	10
Journal	Developmental Brain Research
Volume	62
Issue number	2
DOIs	https://doi.org/10.1016/0165-3806(91)90174-H
Publication status	Published - 21 Oct 1991

Keywords

Afterhyperpolarization
CA1
Depolarizing afterpotential
Development
Hippocampus
Maturation

Access to Document

10.1016/0165-3806(91)90174-H

Cite this

@article{81dac3d38b52490189b9d49d132c9507,

title = "Afterpotential characteristics and firing patterns in maturing rat hippocampal CA1 neurones in in vitro slices",

abstract = "The postnatal evolution of depolarizing after-potentials (DAPs) and after-hyperpolarizations (AHPs) was studied in rat CA1 hippocampal neurones (5-68 days of age) using in vitro slices. Results were pooled into 4 age groups: P5-9, P10-16, P17-24 and P26-68. In P5-9 cells. DAPs were seen as passive signals, with a time constant similar to the time constant of the membrane. The evolution of the DAP was characterized by a decrease in amplitude, an increase in duration and a change in contour. In P10-16 and P17-24 cells, the DAPs often had a plateau or a hump-like shape which increased the probability of firing and the occurrence of spike doublets. The firing pattern and bursting behaviour of P10-16 CA1 neurones differed from the pattern typical of the adult. P5-9 and P10-16 cells had post-burst AHPs with a smaller amplitude and a more prolonged early phase than at late stages of development.",

keywords = "Afterhyperpolarization, CA1, Depolarizing afterpotential, Development, Hippocampus, Maturation",

author = "Costa, {Pedro Freire} and Ribeiro, {Maria Alexandra} and Santos, {Ana Isabel}",

year = "1991",

month = oct,

day = "21",

doi = "10.1016/0165-3806(91)90174-H",

language = "English",

volume = "62",

pages = "263--272",

journal = "Developmental Brain Research",

issn = "0165-3806",

publisher = "Elsevier Science B.V., Amsterdam.",

number = "2",

}

TY - JOUR

T1 - Afterpotential characteristics and firing patterns in maturing rat hippocampal CA1 neurones in in vitro slices

AU - Costa, Pedro Freire

AU - Ribeiro, Maria Alexandra

AU - Santos, Ana Isabel

PY - 1991/10/21

Y1 - 1991/10/21

N2 - The postnatal evolution of depolarizing after-potentials (DAPs) and after-hyperpolarizations (AHPs) was studied in rat CA1 hippocampal neurones (5-68 days of age) using in vitro slices. Results were pooled into 4 age groups: P5-9, P10-16, P17-24 and P26-68. In P5-9 cells. DAPs were seen as passive signals, with a time constant similar to the time constant of the membrane. The evolution of the DAP was characterized by a decrease in amplitude, an increase in duration and a change in contour. In P10-16 and P17-24 cells, the DAPs often had a plateau or a hump-like shape which increased the probability of firing and the occurrence of spike doublets. The firing pattern and bursting behaviour of P10-16 CA1 neurones differed from the pattern typical of the adult. P5-9 and P10-16 cells had post-burst AHPs with a smaller amplitude and a more prolonged early phase than at late stages of development.

AB - The postnatal evolution of depolarizing after-potentials (DAPs) and after-hyperpolarizations (AHPs) was studied in rat CA1 hippocampal neurones (5-68 days of age) using in vitro slices. Results were pooled into 4 age groups: P5-9, P10-16, P17-24 and P26-68. In P5-9 cells. DAPs were seen as passive signals, with a time constant similar to the time constant of the membrane. The evolution of the DAP was characterized by a decrease in amplitude, an increase in duration and a change in contour. In P10-16 and P17-24 cells, the DAPs often had a plateau or a hump-like shape which increased the probability of firing and the occurrence of spike doublets. The firing pattern and bursting behaviour of P10-16 CA1 neurones differed from the pattern typical of the adult. P5-9 and P10-16 cells had post-burst AHPs with a smaller amplitude and a more prolonged early phase than at late stages of development.

KW - Afterhyperpolarization

KW - CA1

KW - Depolarizing afterpotential

KW - Development

KW - Hippocampus

KW - Maturation

UR - http://www.scopus.com/inward/record.url?scp=0025936185&partnerID=8YFLogxK

U2 - 10.1016/0165-3806(91)90174-H

DO - 10.1016/0165-3806(91)90174-H

M3 - Article

C2 - 1769105

AN - SCOPUS:0025936185

SN - 0165-3806

VL - 62

SP - 263

EP - 272

JO - Developmental Brain Research

JF - Developmental Brain Research

IS - 2

ER -

Afterpotential characteristics and firing patterns in maturing rat hippocampal CA1 neurones in in vitro slices

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this