Afadin Signaling at the Spinal Neuroepithelium Regulates Central Canal Formation and Gait Selection

Sophie Skarlatou, Coralie Hérent, Elisa Toscano, César S. Mendes, Julien Bouvier, Niccolò Zampieri

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Abstract

Skarlatou et al. report that afadin function in the developing spinal neuroepithelium controls organization of the midline. Afadin elimination from the motor neuron progenitor zone results in duplication of the central canal, aberrant wiring of dI4-5, V0, and V2a premotor neurons, and loss of left-right limb alternation.

Original languageEnglish
Article number107741
JournalCell Reports
Volume31
Issue number10
DOIs
Publication statusPublished - 9 Jun 2020

Keywords

  • Afadin
  • central canal development
  • gait
  • locomotor circuits
  • premotor connectivity
  • spinal cord
  • spinal interneurons

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