TY - JOUR
T1 - Advances in sesquiterpene lactones extraction
AU - Brás, Teresa
AU - Neves, Luísa A.
AU - Crespo, João G.
AU - Duarte, Maria F.
N1 - Funding Information:
info:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F110969%2F2015/PT#
info:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F00505%2F2014%2FCP1224%2FCT0004/PT#
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT#
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F05183%2F2020/PT#
The authors want to thank to Regional Development European Foundation and Alentejo Region Operational Program (ALENTEJO 2020) for their financial support to “MedCynaraBioTec – Selection of Cynara cardunculus genotypes for new Biotechnological applications: the value chain improvement of cardoon, a well-adapted Mediterranean crop” (ALT20-03-0145-FEDER-039495); and “ValBioTecCynara - Economic Valorization of Cardoon (Cynara cardunculus): Study of natural variability and biotechnological applications” Project (ALT20-03-0145-FEDER-000038).
This work was also funded through FCT under the Project LA/P/0121/2020 to CHANGE – Global Change and Sustainability Institute .
Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2023/1
Y1 - 2023/1
N2 - Sesquiterpene lactones (SL) group, comprises more than 6000 compounds, with high biological potential. Access to SL biological potential could be achieved by solid-liquid extraction, with solvent and extraction process as key factors for a successful extraction. SL research has been mainly focused on compounds identification, with a large range of solvents being applied, not all corresponding to the European Medicines Agency guidelines, using different conventional extraction methodologies. Moreover, there is still a lack of scientific knowledge regarding the extraction solvent and methodology effect upon SL extraction from plants, and its bioactivity, towards final applications. This review aims to provide a perspective regarding the impact of extraction solvents and methodologies upon SL extraction efficiency, as well as the purification methods applied till date, highlighting the overall impact on final extraction efficiency, underlying pertinent aspects for future economic valorization opportunities, as well research challenges towards industrial applications regarding SL plants extraction.
AB - Sesquiterpene lactones (SL) group, comprises more than 6000 compounds, with high biological potential. Access to SL biological potential could be achieved by solid-liquid extraction, with solvent and extraction process as key factors for a successful extraction. SL research has been mainly focused on compounds identification, with a large range of solvents being applied, not all corresponding to the European Medicines Agency guidelines, using different conventional extraction methodologies. Moreover, there is still a lack of scientific knowledge regarding the extraction solvent and methodology effect upon SL extraction from plants, and its bioactivity, towards final applications. This review aims to provide a perspective regarding the impact of extraction solvents and methodologies upon SL extraction efficiency, as well as the purification methods applied till date, highlighting the overall impact on final extraction efficiency, underlying pertinent aspects for future economic valorization opportunities, as well research challenges towards industrial applications regarding SL plants extraction.
KW - Biological activity
KW - Extraction methodology
KW - Extraction solvents
KW - Purification
KW - Sesquiterpene lactones
UR - http://www.scopus.com/inward/record.url?scp=85145589364&partnerID=8YFLogxK
U2 - 10.1016/j.trac.2022.116838
DO - 10.1016/j.trac.2022.116838
M3 - Review article
AN - SCOPUS:85145589364
SN - 0165-9936
VL - 158
JO - TrAC - Trends in Analytical Chemistry
JF - TrAC - Trends in Analytical Chemistry
M1 - 116838
ER -