Adipose tissue fatty acids as biomarkers for metabolic dysfunction in obese females: Implication of menopause and ageing

Sara Sousa, Diogo Pestana, Gil Faria, Cristina Delerue-Matos, Conceição Calhau, Valentina Fernandes Domingues

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Abstract

Fatty acids (FA) are biomarkers of metabolic dysfunction. Adipose tissue is the largest reservoir of FA and acts differently in obese individuals. Menopause by itself significantly alters metabolism, lipid metabolism dysregulation, and adipose tissue distribution. How adipose tissue FA alters an obese individual's metabolism depending on a female's menopausal status is yet poorly understood. Hence, the subcutaneous (scAT) and visceral adipose tissue (vAT) FA profile for 173 obese premenopausal and postmenopausal women was measured and associated with biochemical parameters. scAT and vAT FA profiles were distinct by themselves and in menopause. In total 816 associations were found with biochemical parameters, where only 58 were independent of the menopausal status. The associations found to emphasize the importance of assessing the adipose tissue FA profile and how their behavior changes with menopause. The FA are crucial in metabolic processes and can be helpful biomarkers in the prevention/treatment and follow-up of female obesity.

Original languageEnglish
Article number102581
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume195
DOIs
Publication statusPublished - Aug 2023

Keywords

  • Adipocytes
  • Biochemical parameters
  • Lipid
  • Metabolism
  • Obesity
  • Women

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