Adenovirus vector production and purification

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Abstract

Replication deficient adenovirus vectors are frequently used tools for the delivery of transgenes in vitro and in vivo. In addition, several therapeutic products based on adenovirus are under clinical development. This review outlines adenovirus vector production discussing different vector types, available production cell lines and state of the art of production process development and purification.
Original languageUnknown
Pages (from-to)437-455
JournalCurrent Gene Therapy
Volume10
Issue number6
Publication statusPublished - 1 Jan 2010

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