Adenosine Receptor Blockade by Caffeine Inhibits Carotid Sinus Nerve Chemosensory Activity in Chronic Intermittent Hypoxic Animals

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Abstract

Adenosine is a key excitatory neurotransmitter at the synapse between O-2-sensing chemoreceptor cells-carotid sinus nerve (CSN) endings in the carotid body (CB). Herein, we have investigated the significance of adenosine, through the blockade of its receptors with caffeine, on the CB hypoxic sensitization induced by chronic intermittent hypoxia (CIH) in the rat. CIH animals were obtained by submitting rats during 15 days from 8:00 to 16:00 to 10 \%O-2 for 40 s and 20 \%O-2 for 80 s (i.e., 30 episodes/h). Caffeine (1 mM) was tested in spontaneous and 5 \%O-2 evoked-CSN chemosensory activity in normoxic and CIH animals. CIH decreased basal spontaneous activity but increased significantly CSN activity evoked by acute hypoxia. Caffeine did not modify basal spontaneous activity in normoxic rats, but decreased significantly by 47.83 \% basal activity in CIH animals. In addition, acute application of caffeine decreased 49.31 \% and 56.01 \% the acute hypoxic response in normoxic and CIH animals, respectively. We demonstrate that adenosine contributes to fix CSN basal activity during CIH, being also involved in hypoxic CB chemotransduction. It is concluded that adenosine participates in CB sensitization during CIH.
Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
EditorsC Peers, P Kumar, C Wyatt, E Gauda, C Nurse, N Prabhakar
Place of PublicationHEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
PublisherSPRINGER-VERLAG BERLIN
Pages133-137
Volume860
ISBN (Print)978-3-319-18440-1; 978-3-319-18439-5
DOIs
Publication statusPublished - 2015
Event18th Meeting of the International-Society-for-Arterial-Chemoreception -
Duration: 1 Jan 2014 → …

Conference

Conference18th Meeting of the International-Society-for-Arterial-Chemoreception
Period1/01/14 → …

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    Conde, S., & Sacramento, J. F. (2015). Adenosine Receptor Blockade by Caffeine Inhibits Carotid Sinus Nerve Chemosensory Activity in Chronic Intermittent Hypoxic Animals. In C. Peers, P. Kumar, C. Wyatt, E. Gauda, C. Nurse, & N. Prabhakar (Eds.), Advances in Experimental Medicine and Biology (Vol. 860, pp. 133-137). HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY: SPRINGER-VERLAG BERLIN. https://doi.org/10.1007/978-3-319-18440-1\_15