Adenosine-Monophosphate-Assisted Homogeneous Silica Coating of Silver Nanoparticles in High Yield

Carlos Fernández-Lodeiro, Reem Tambosi, Javier Fernández-Lodeiro, Adrián Fernández-Lodeiro, Silvia Nuti, Soufian Ouchane, Nouari Kébaïli, Jorge Pérez-Juste, Isabel Pastoriza-Santos, Carlos Lodeiro

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


In this study, we propose a novel approach for the silica coating of silver nanoparticles based on surface modification with adenosine monophosphate (AMP). Upon AMP stabilization, the nanoparticles can be transferred into 2-propanol, promoting the growth of silica on the particle surfaces through the standard Stöber process. The obtained silica shells are uniform and homogeneous, and the method allows a high degree of control over shell thickness while minimizing the presence of uncoated NPs or the negligible presence of core-free silica NPs. In addition, AMP-functionalized AgNPs could be also coated with a mesoporous silica shell using cetyltrimethylammonium chloride (CTAC) as a template. Interestingly, the thickness of the mesoporous silica coating could be tightly adjusted by either the silica precursor concentration or by varying the CTAC concentration while keeping the silica precursor concentration constant. Finally, the influence of the silica coating on the antimicrobial effect of AgNPs was studied on Gram-negative bacteria (R. gelatinosus and E. coli) and under different bacterial growth conditions, shedding light on their potential applications in different biological environments.
Original languageEnglish
Article number2788
Number of pages16
Issue number20
Publication statusPublished - 18 Oct 2023


  • adenosine monophosphate
  • bactericidal properties
  • mesoporous silica
  • silica coating
  • silver nanoparticles


Dive into the research topics of 'Adenosine-Monophosphate-Assisted Homogeneous Silica Coating of Silver Nanoparticles in High Yield'. Together they form a unique fingerprint.

Cite this